Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3886949..3887676 Replicon chromosome
Accession NZ_CP071375
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J0O73_RS18795 Protein ID WP_096220540.1
Coordinates 3887365..3887676 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0O73_RS18790 Protein ID WP_000126294.1
Coordinates 3886949..3887368 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS18770 3881999..3882526 - 528 WP_153645451.1 electron transport protein HydN -
J0O73_RS18775 3882675..3883685 - 1011 WP_024262311.1 DNA-binding transcriptional regulator AscG -
J0O73_RS18780 3883945..3885402 + 1458 WP_001107820.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
J0O73_RS18785 3885411..3886835 + 1425 WP_000110316.1 6-phospho-beta-glucosidase AscB -
J0O73_RS18790 3886949..3887368 - 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
J0O73_RS18795 3887365..3887676 - 312 WP_096220540.1 type II toxin-antitoxin system HigB family toxin Toxin
J0O73_RS18800 3887838..3888593 - 756 WP_001360181.1 hypothetical protein -
J0O73_RS18805 3888636..3889106 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
J0O73_RS18810 3889099..3889509 - 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
J0O73_RS18815 3889506..3890273 - 768 WP_000067401.1 formate hydrogenlyase subunit HycG -
J0O73_RS18820 3890273..3890815 - 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
J0O73_RS18825 3890825..3892534 - 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12426.17 Da        Isoelectric Point: 9.7105

>T196234 WP_096220540.1 NZ_CP071375:c3887676-3887365 [Escherichia coli]
MHIISKVPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T196234 NZ_CP095023:c1577954-1577553 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT196234 WP_000126294.1 NZ_CP071375:c3887368-3886949 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT196234 NZ_CP095023:c1578208-1577951 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References