Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1011544..1012085 Replicon chromosome
Accession NZ_CP071375
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag J0O73_RS04810 Protein ID WP_096220693.1
Coordinates 1011544..1011822 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag J0O73_RS04815 Protein ID WP_000729704.1
Coordinates 1011825..1012085 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS04795 1009126..1009704 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
J0O73_RS04800 1009910..1010677 + 768 WP_000333380.1 class II glutamine amidotransferase -
J0O73_RS04805 1010648..1011388 - 741 WP_001225679.1 murein L,D-transpeptidase -
J0O73_RS04810 1011544..1011822 - 279 WP_096220693.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
J0O73_RS04815 1011825..1012085 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
J0O73_RS04820 1012295..1013044 + 750 WP_053884036.1 C40 family peptidase -
J0O73_RS04825 1013101..1013457 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
J0O73_RS04830 1013450..1013728 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
J0O73_RS04835 1013833..1015545 - 1713 Protein_924 flagellar biosynthesis protein FlhA -
J0O73_RS04840 1015517..1016302 + 786 WP_000207551.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10844.60 Da        Isoelectric Point: 9.9107

>T196216 WP_096220693.1 NZ_CP071375:c1011822-1011544 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHNDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAVLFG

Download         Length: 279 bp

>T196216 NZ_CP095023:679236-679643 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT196216 WP_000729704.1 NZ_CP071375:c1012085-1011825 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT196216 NZ_CP095023:679024-679239 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References