Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 911130..911782 Replicon chromosome
Accession NZ_CP071320
Organism Serratia ureilytica strain T6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J0X03_RS04210 Protein ID WP_160204538.1
Coordinates 911438..911782 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0X03_RS04205 Protein ID WP_025304078.1
Coordinates 911130..911432 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X03_RS04180 906138..906785 - 648 WP_033644834.1 DsbA family protein -
J0X03_RS04185 906854..907738 - 885 WP_046687735.1 MBL fold metallo-hydrolase -
J0X03_RS04190 907847..908755 + 909 WP_033644836.1 LysR family transcriptional regulator -
J0X03_RS04195 908783..909706 - 924 WP_042785280.1 LysR family transcriptional regulator -
J0X03_RS04200 909840..911102 + 1263 WP_033644838.1 diaminopimelate decarboxylase -
J0X03_RS04205 911130..911432 - 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
J0X03_RS04210 911438..911782 - 345 WP_160204538.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0X03_RS04215 911941..912960 - 1020 WP_033652132.1 HTH-type transcriptional regulator GalR -
J0X03_RS04220 913181..915439 + 2259 WP_160204537.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13353.42 Da        Isoelectric Point: 10.8296

>T196179 WP_160204538.1 NZ_CP071320:c911782-911438 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSEAARQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T196179 NZ_CP095022:c1941491-1941102 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT196179 WP_025304078.1 NZ_CP071320:c911432-911130 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT196179 NZ_CP095022:c1941715-1941488 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References