Detailed information of TA system TA196168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2162304..2162897
• Replicon: chromosome
• Accession: NZ_CP071311
• Organism: Rhizobium sp. X9

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JZY08_RS10605
• Protein ID: WP_216331549.1
• Coordinates: 2162304..2162570 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JZY08_RS10610
• Protein ID: WP_216330108.1
• Coordinates: 2162646..2162897 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY08_RS10580	2157767..2158489	+	723	WP_216331547.1	sulfite exporter TauE/SafE family protein	-
JZY08_RS10585	2158567..2159700	+	1134	WP_216330105.1	alpha-hydroxy acid oxidase	-
JZY08_RS10590	2159913..2160257	-	345	WP_216330106.1	multidrug efflux SMR transporter	-
JZY08_RS10595	2160254..2160826	-	573	WP_216330107.1	TetR/AcrR family transcriptional regulator	-
JZY08_RS10600	2161029..2162300	+	1272	WP_216331548.1	D-alanyl-D-alanine carboxypeptidase	-
JZY08_RS10605	2162304..2162570	-	267	WP_216331549.1	Txe/YoeB family addiction module toxin	Toxin
JZY08_RS10610	2162646..2162897	-	252	WP_216330108.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JZY08_RS10615	2162951..2163700	-	750	WP_216330109.1	metallophosphoesterase family protein	-
JZY08_RS10620	2163706..2164062	-	357	WP_082182777.1	hydroxyisourate hydrolase	-
JZY08_RS10625	2164059..2164559	-	501	WP_035241797.1	ureidoglycolate lyase	-
JZY08_RS10630	2164562..2164924	-	363	WP_216330110.1	DUF86 domain-containing protein	-
JZY08_RS10635	2164921..2165211	-	291	WP_216330111.1	nucleotidyltransferase family protein	-
JZY08_RS10640	2165265..2165762	-	498	WP_216330112.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JZY08_RS10645	2165762..2166685	-	924	WP_216330113.1	allantoinase PuuE	-
JZY08_RS10650	2166888..2167595	-	708	WP_003491610.1	DUF1045 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10902.55 Da
• Isoelectric Point: 8.7279

>T196168 WP_216331549.1 NZ_CP071311:c2162570-2162304 [Rhizobium sp. X9]
IALCWSHQGWEDYLHWQQYDRKMLERINELIKDCRRHPFEGIGKPEPLRFQLKGLWSRRISQEHRLVYELRGEGEKTVLI
IHQCRFHY

Nucleotide

• Length: 267 bp

>T196168 NZ_CP095022:c754659-754222 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9414.68 Da
• Isoelectric Point: 4.5242

>AT196168 WP_216330108.1 NZ_CP071311:c2162897-2162646 [Rhizobium sp. X9]
MRTVMFSKARESLASLLDEVAQDRVTVEIVRRDKPSAVLIDKDEYEGLMETLHLCSSPENFARLRKSMSDVDAGVFESHD
LID

Nucleotide

• Length: 252 bp

>AT196168 NZ_CP095022:c754910-754656 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA