Detailed information of TA system TA196164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2138975..2139494
• Replicon: chromosome
• Accession: NZ_CP071305
• Organism: Streptococcus suis strain SC183

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JZY07_RS10530
• Protein ID: WP_024399851.1
• Coordinates: 2138975..2139232 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0M9FLP3
• Locus tag: JZY07_RS10535
• Protein ID: WP_029693536.1
• Coordinates: 2139234..2139494 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY07_RS10515	2135443..2137173	-	1731	WP_024399848.1	membrane protein	-
JZY07_RS10520	2137535..2138443	-	909	WP_079268007.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
JZY07_RS10525	2138427..2138957	-	531	WP_024399850.1	DUF1697 domain-containing protein	-
JZY07_RS10530	2138975..2139232	-	258	WP_024399851.1	Txe/YoeB family addiction module toxin	Toxin
JZY07_RS10535	2139234..2139494	-	261	WP_029693536.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JZY07_RS10540	2139570..2140025	-	456	WP_024399853.1	8-oxo-dGTP diphosphatase	-
JZY07_RS10545	2140045..2140473	-	429	WP_153308708.1	DUF3916 domain-containing protein	-
JZY07_RS10550	2140564..2141166	-	603	WP_061630795.1	ribonuclease M5	-
JZY07_RS10555	2141129..2141911	-	783	WP_024399856.1	TatD family hydrolase	-
JZY07_RS10560	2142018..2142155	-	138	WP_002939016.1	50S ribosomal protein L34	-
JZY07_RS10565	2142323..2143318	-	996	WP_013730624.1	protein jag	-
JZY07_RS10570	2143338..2144150	-	813	WP_012027897.1	YidC/Oxa1 family membrane protein insertase	-
JZY07_RS10575	2144134..2144493	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10273.80 Da
• Isoelectric Point: 7.2737

>T196164 WP_024399851.1 NZ_CP071305:c2139232-2138975 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKILKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYG

Nucleotide

• Length: 258 bp

>T196164 NZ_CP095022:716636-717043 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.29 Da
• Isoelectric Point: 5.1255

>AT196164 WP_029693536.1 NZ_CP071305:c2139494-2139234 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Nucleotide

• Length: 261 bp

>AT196164 NZ_CP095022:716379-716639 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0M9FLP3