Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3656601..3657198 Replicon chromosome
Accession NZ_CP071279
Organism Klebsiella pneumoniae subsp. pneumoniae strain SA-KpST14

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JZ794_RS17890 Protein ID WP_004142563.1
Coordinates 3656881..3657198 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JZ794_RS17885 Protein ID WP_004142561.1
Coordinates 3656601..3656888 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ794_RS17855 3652681..3652929 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JZ794_RS17860 3652947..3653288 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JZ794_RS17865 3653319..3654434 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
JZ794_RS17870 3654614..3655195 + 582 WP_043906838.1 TetR/AcrR family transcriptional regulator -
JZ794_RS17875 3655195..3655563 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JZ794_RS17880 3655683..3656333 + 651 Protein_3506 oxygen-insensitive NAD(P)H nitroreductase -
JZ794_RS17885 3656601..3656888 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JZ794_RS17890 3656881..3657198 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZ794_RS17895 3657383..3658426 - 1044 WP_004178895.1 DUF2157 domain-containing protein -
JZ794_RS17900 3659093..3659959 - 867 WP_004178894.1 helix-turn-helix transcriptional regulator -
JZ794_RS17905 3660068..3661495 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T196148 WP_004142563.1 NZ_CP071279:c3657198-3656881 [Klebsiella pneumoniae subsp. pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T196148 NZ_CP095021:c3694805-3694377 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT196148 WP_004142561.1 NZ_CP071279:c3656888-3656601 [Klebsiella pneumoniae subsp. pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT196148 NZ_CP095021:c3695051-3694809 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References