Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4535863..4536593 Replicon chromosome
Accession NZ_CP071236
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S13_jyu2015

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag J0F82_RS21700 Protein ID WP_004937033.1
Coordinates 4535863..4536174 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0F82_RS21705 Protein ID WP_015379178.1
Coordinates 4536171..4536593 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F82_RS21670 4531176..4531901 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
J0F82_RS21675 4531954..4533387 + 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
J0F82_RS21680 4533411..4533698 + 288 WP_004937038.1 ribosome hibernation promoting factor -
J0F82_RS21685 4533854..4534315 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
J0F82_RS21690 4534445..4535299 + 855 WP_015379177.1 RNase adapter RapZ -
J0F82_RS21695 4535296..4535568 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
J0F82_RS21700 4535863..4536174 + 312 WP_004937033.1 type II toxin-antitoxin system HigB family toxin Toxin
J0F82_RS21705 4536171..4536593 + 423 WP_015379178.1 helix-turn-helix domain-containing protein Antitoxin
J0F82_RS21710 4536597..4538513 - 1917 WP_033639303.1 BglG family transcription antiterminator -
J0F82_RS21715 4538565..4539779 - 1215 WP_033639302.1 lactonase family protein -
J0F82_RS21720 4540056..4540796 - 741 WP_016930215.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T195932 WP_004937033.1 NZ_CP071236:4535863-4536174 [Serratia marcescens subsp. marcescens ATCC 13880]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T195932 NZ_CP094940:1981785-1981887 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT195932 WP_015379178.1 NZ_CP071236:4536171-4536593 [Serratia marcescens subsp. marcescens ATCC 13880]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT195932 NZ_CP094940:c1981894-1981749 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GR63

Antitoxin

Source ID Structure

References