Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4534584..4535314 Replicon chromosome
Accession NZ_CP071230
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S40_jyu2015

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag J0F80_RS21690 Protein ID WP_004937033.1
Coordinates 4534584..4534895 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0F80_RS21695 Protein ID WP_015379178.1
Coordinates 4534892..4535314 (+) Length 141 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F80_RS21660 4529897..4530622 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
J0F80_RS21665 4530675..4532108 + 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
J0F80_RS21670 4532132..4532419 + 288 WP_004937038.1 ribosome hibernation promoting factor -
J0F80_RS21675 4532575..4533036 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
J0F80_RS21680 4533166..4534020 + 855 WP_015379177.1 RNase adapter RapZ -
J0F80_RS21685 4534017..4534289 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
J0F80_RS21690 4534584..4534895 + 312 WP_004937033.1 type II toxin-antitoxin system HigB family toxin Toxin
J0F80_RS21695 4534892..4535314 + 423 WP_015379178.1 helix-turn-helix domain-containing protein Antitoxin
J0F80_RS21700 4535318..4537234 - 1917 WP_033639303.1 BglG family transcription antiterminator -
J0F80_RS21705 4537286..4538500 - 1215 WP_033639302.1 lactonase family protein -
J0F80_RS21710 4538777..4539517 - 741 WP_016930215.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T195884 WP_004937033.1 NZ_CP071230:4534584-4534895 [Serratia marcescens subsp. marcescens ATCC 13880]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T195884 NZ_CP094924:c957390-957238 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT195884 WP_015379178.1 NZ_CP071230:4534892-4535314 [Serratia marcescens subsp. marcescens ATCC 13880]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT195884 NZ_CP094924:c958014-957415 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGACACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A8B4GR63


Antitoxin

Source ID Structure

References