Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4534624..4535354 Replicon chromosome
Accession NZ_CP071226
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S22_jyu2015

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag J0G07_RS21690 Protein ID WP_004937033.1
Coordinates 4534624..4534935 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0G07_RS21695 Protein ID WP_015379178.1
Coordinates 4534932..4535354 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G07_RS21660 4529937..4530662 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
J0G07_RS21665 4530715..4532148 + 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
J0G07_RS21670 4532172..4532459 + 288 WP_004937038.1 ribosome hibernation promoting factor -
J0G07_RS21675 4532615..4533076 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
J0G07_RS21680 4533206..4534060 + 855 WP_015379177.1 RNase adapter RapZ -
J0G07_RS21685 4534057..4534329 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
J0G07_RS21690 4534624..4534935 + 312 WP_004937033.1 type II toxin-antitoxin system HigB family toxin Toxin
J0G07_RS21695 4534932..4535354 + 423 WP_015379178.1 helix-turn-helix domain-containing protein Antitoxin
J0G07_RS21700 4535358..4537274 - 1917 WP_033639303.1 BglG family transcription antiterminator -
J0G07_RS21705 4537326..4538540 - 1215 WP_033639302.1 lactonase family protein -
J0G07_RS21710 4538817..4539557 - 741 WP_016930215.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T195852 WP_004937033.1 NZ_CP071226:4534624-4534935 [Serratia marcescens subsp. marcescens ATCC 13880]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T195852 NZ_CP094857:c1987782-1987606 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT195852 WP_015379178.1 NZ_CP071226:4534932-4535354 [Serratia marcescens subsp. marcescens ATCC 13880]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT195852 NZ_CP094857:1987483-1987538 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GR63

Antitoxin

Source ID Structure

References