Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 62963..63609 Replicon chromosome
Accession NZ_CP071178
Organism Enterobacter kobei strain CDL29

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JZY03_RS00325 Protein ID WP_063434484.1
Coordinates 63259..63609 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JZY03_RS00320 Protein ID WP_063614463.1
Coordinates 62963..63262 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY03_RS00290 (JZY03_00295) 58377..59336 - 960 WP_063614467.1 DUF523 and DUF1722 domain-containing protein -
JZY03_RS00295 (JZY03_00300) 59439..59849 - 411 WP_014881954.1 hydroxyisourate hydrolase -
JZY03_RS00300 (JZY03_00305) 59949..60674 - 726 WP_063614466.1 MerR family transcriptional regulator -
JZY03_RS00305 (JZY03_00310) 60792..61316 + 525 WP_014881956.1 lipocalin family protein -
JZY03_RS00310 (JZY03_00315) 61395..62393 + 999 WP_063614465.1 class I SAM-dependent methyltransferase -
JZY03_RS00315 (JZY03_00320) 62496..62933 + 438 WP_063614464.1 acetyltransferase -
JZY03_RS00320 (JZY03_00325) 62963..63262 - 300 WP_063614463.1 XRE family transcriptional regulator Antitoxin
JZY03_RS00325 (JZY03_00330) 63259..63609 - 351 WP_063434484.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZY03_RS00330 63857..64052 - 196 Protein_65 hydroxyacid dehydrogenase -
JZY03_RS00335 (JZY03_00335) 64154..64495 - 342 WP_063614462.1 SymE family type I addiction module toxin -
JZY03_RS00340 (JZY03_00340) 64623..64814 + 192 WP_063614481.1 toxin-antitoxin system HicB family antitoxin -
JZY03_RS00345 (JZY03_00345) 64880..66091 + 1212 WP_063614461.1 DUF3644 domain-containing protein -
JZY03_RS00355 (JZY03_00355) 66484..67875 + 1392 WP_250365937.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13497.52 Da        Isoelectric Point: 6.9811

>T195514 WP_063434484.1 NZ_CP071178:c63609-63259 [Enterobacter kobei]
MWTVLFGKVFELWLLEQEEGLQEKVLADMLNLQNYGPRLPRPYADTVKGSQYNNMKELRIQYAGRPIRALFAFDPERQAI
VLCAGNKSNDKAFYEKLIRIADDEFTRHLTSLETAK

Download         Length: 351 bp

>T195514 NZ_CP094750:c2450333-2450067 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAGATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11190.06 Da        Isoelectric Point: 6.9842

>AT195514 WP_063614463.1 NZ_CP071178:c63262-62963 [Enterobacter kobei]
VKTLNELITSRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT195514 NZ_CP094750:c2450584-2450333 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References