Detailed information of TA system TA195509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2645909..2646246
• Replicon: chromosome
• Accession: NZ_CP071176
• Organism: Enterococcus faecalis strain L18

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: JZP79_RS12840
• Protein ID: WP_002396786.1
• Coordinates: 2645909..2646052 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2645984..2646246 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZP79_RS12820	2641125..2641340	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
JZP79_RS12825	2641479..2642471	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
JZP79_RS12830	2642638..2643276	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
JZP79_RS12835	2643961..2645577	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
JZP79_RS12840	2645909..2646052	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2645984..2646246	-	263	-	-	Antitoxin
JZP79_RS12845	2646247..2650938	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T195509 WP_002396786.1 NZ_CP071176:2645909-2646052 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T195509 NZ_CP094750:c872740-872552 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT195509 NZ_CP071176:c2646246-2645984 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin