Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 84595..84931 Replicon chromosome
Accession NZ_CP071172
Organism Enterococcus faecalis strain L13

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag JZP77_RS00360 Protein ID WP_002396786.1
Coordinates 84788..84931 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 84595..84644 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZP77_RS00355 79902..84593 + 4692 WP_002378865.1 WxL domain-containing protein -
- 84595..84644 - 50 - - Antitoxin
JZP77_RS00360 84788..84931 - 144 WP_002396786.1 putative holin-like toxin Toxin
JZP77_RS00365 85263..86879 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
JZP77_RS00370 87564..88202 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
JZP77_RS00375 88369..89361 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
JZP77_RS00380 89500..89715 + 216 WP_002354768.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T195497 WP_002396786.1 NZ_CP071172:c84931-84788 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T195497 NZ_CP094743:c2506877-2506611 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 50 bp

>AT195497 NZ_CP071172:c84644-84595 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References