Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3693021..3693618 Replicon chromosome
Accession NZ_CP071150
Organism Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JZ790_RS18145 Protein ID WP_004142563.1
Coordinates 3693021..3693338 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JZ790_RS18150 Protein ID WP_004142561.1
Coordinates 3693331..3693618 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ790_RS18130 3688725..3690152 - 1428 WP_004176980.1 MFS transporter -
JZ790_RS18135 3690261..3691127 + 867 WP_048299254.1 helix-turn-helix transcriptional regulator -
JZ790_RS18140 3691793..3692836 + 1044 WP_135707754.1 DUF2157 domain-containing protein -
JZ790_RS18145 3693021..3693338 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZ790_RS18150 3693331..3693618 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JZ790_RS18155 3693883..3694536 - 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JZ790_RS18160 3694656..3695024 - 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JZ790_RS18165 3695024..3695605 - 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JZ790_RS18170 3695785..3696900 + 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JZ790_RS18175 3696931..3697272 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JZ790_RS18180 3697290..3697538 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T195488 WP_004142563.1 NZ_CP071150:3693021-3693338 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T195488 NZ_CP094742:718246-718599 [Staphylococcus chromogenes]
ATGAAGCGTGGCGATGTTTATTTAGCGGATTTATCACCAGTACAAGGGTCAGAGCAAGGGGGAGTCAGACCTGTCGTTAT
TATTCAAAATGATACTGGTAATAAATACAGTCCGACCGTGATTGTTGCAGCGATTACAGGTCGCATCAATAAAGCGAAAA
TTCCAACGCATGTCGAAATTGATAAGAAAAAATATAAACTCGACAAAGATTCTGTTATTTTGTTAGAACAAATTAGAACA
GTCGATAAAAAGAGGCTTAAAGAAAAGCTCACCTTTCTTTCTGATAAAAAGATGAAAGAGGTTAATGCGGCACTTGGAAT
TAGCTTAGGATTGCACATGAATCAACACAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT195488 WP_004142561.1 NZ_CP071150:3693331-3693618 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT195488 NZ_CP094742:718075-718245 [Staphylococcus chromogenes]
ATGTCAGCATTCAATCAAACAAGAGTGAAAAGTTTAGAGCAATCTTTGAAAGAGGGGTATGTTCAGATGGCAGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTTTGTCGAATGTGAAGCATGTGATTGCAACGAATCACACTTACTTTCTAACCACA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References