Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 134861..135447 Replicon chromosome
Accession NZ_CP071150
Organism Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag JZ790_RS00580 Protein ID WP_002920800.1
Coordinates 135079..135447 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag JZ790_RS00575 Protein ID WP_004174006.1
Coordinates 134861..135082 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ790_RS00555 131018..131944 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JZ790_RS00560 131941..133218 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
JZ790_RS00565 133215..133982 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JZ790_RS00570 133984..134697 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JZ790_RS00575 134861..135082 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JZ790_RS00580 135079..135447 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JZ790_RS00585 135721..137037 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JZ790_RS00590 137144..138031 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JZ790_RS00595 138028..138873 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JZ790_RS00600 138875..139945 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 131941..140682 8741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T195475 WP_002920800.1 NZ_CP071150:135079-135447 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T195475 NZ_CP094736:841948-842169 [Staphylococcus delphini]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGAGTGTTGTTATTGATTTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCATATAAAGGAGTGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT195475 WP_004174006.1 NZ_CP071150:134861-135082 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT195475 NZ_CP094736:841648-841935 [Staphylococcus delphini]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGTTGCATCATGCATAAGATTGACGCAGGGCACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACGTTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References