195448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3799239..3799906 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag JZL63_RS17675 Protein ID WP_003417916.1
Coordinates 3799239..3799631 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag JZL63_RS17680 Protein ID WP_003912214.1
Coordinates 3799631..3799906 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS17665 3796444..3797433 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JZL63_RS17670 3797433..3798485 - 1053 WP_206280483.1 polyprenyl synthetase family protein -
JZL63_RS17675 3799239..3799631 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
JZL63_RS17680 3799631..3799906 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JZL63_RS17685 3800118..3801459 + 1342 Protein_3493 ISNCY family transposase -
JZL63_RS17690 3801649..3803844 + 2196 WP_206280484.1 PE domain-containing protein -
JZL63_RS17695 3803915..3804787 - 873 WP_206280485.1 MaoC family dehydratase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3795096..3801459 6363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T195448 WP_003417916.1 NZ_CP071128:c3799631-3799239 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T195448 NZ_CP094725:914059-914283 [Staphylococcus felis]
ATGTATCAAAGTTATGTGCAAGTCTCGAACATTCAAACAGAAAATGATAAAGAAGCTTTAGAAAATCGTTTATCTTCTAT
GATTGGGGTATTGGATGTTCAAATTGATATCAATCAGCAATGTGTCAACCTAGAATATGAAACACCAGCAAATCTTAACA
CGTTAGAAAAAGAAATCTATGATGCAGGTTTTCCTGTTATCAATTCATTCAAAGGAGGACATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT195448 WP_003912214.1 NZ_CP071128:c3799906-3799631 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT195448 NZ_CP094725:913759-914046 [Staphylococcus felis]
ATGACTGAACAAGCACATCATTCTGATTCGATAAAGCGTAATTTAAAGTCGCGTTTGAATCGTATTGAAGGACAAGTACG
TGCCATCAATCGTATGATAGATGAAGATGTCTATTGTGATGATGTTTTAACGCAAATTAGAGCAACACGATCTGCTTTAA
ATAGCGTAGCGACAAAATTATTAGATTATCACATGAAAGGTTGTATTATGCATAAAATTGAAAATGGTTCTGAACAAGAA
GCTATGGAAGAATTACTTGTGACGTTCCAGAAATTAATGAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References