Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976582..2977230 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JZL63_RS13890 Protein ID WP_003899414.1
Coordinates 2976582..2976905 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JZL63_RS13895 Protein ID WP_003899415.1
Coordinates 2976985..2977230 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS13870 2972156..2973417 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
JZL63_RS13875 2973791..2975230 - 1440 WP_206280325.1 phage major capsid protein -
JZL63_RS13880 2975238..2975771 - 534 WP_003899412.1 HK97 family phage prohead protease -
JZL63_RS13885 2975924..2976415 - 492 WP_206280326.1 phage terminase small subunit P27 family -
JZL63_RS13890 2976582..2976905 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JZL63_RS13895 2976985..2977230 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JZL63_RS13900 2977227..2978654 - 1428 WP_206280327.1 DUF3631 domain-containing protein -
JZL63_RS13905 2978656..2979048 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JZL63_RS13910 2979045..2979305 - 261 WP_206280328.1 excisionase family DNA-binding protein -
JZL63_RS13915 2979322..2979684 - 363 WP_003900543.1 hypothetical protein -
JZL63_RS13920 2979687..2980814 - 1128 WP_003899420.1 site-specific integrase -
JZL63_RS13925 2980959..2981186 - 228 WP_003899421.1 hypothetical protein -
JZL63_RS13930 2981183..2981572 - 390 WP_003899422.1 hypothetical protein -
JZL63_RS13935 2981478..2981750 + 273 WP_003900544.1 hypothetical protein -
JZL63_RS13940 2981849..2982082 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970547..2980814 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T195437 WP_003899414.1 NZ_CP071128:c2976905-2976582 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T195437 NZ_CP094722:c1459853-1459695 [Staphylococcus sp. IVB6218]
ATGAATAAACAAGAAAATGAACATGGCATGGTTGACAGCTTTGATGAAGTTGTTGAGTTAGGTAAAGAGATGGAACAAAT
CTCTGAAGAAAATGATGAAGAAAAGTATGAACAGTCACACGAGGAAGCGGTTCGTAGTGATCGTGAGACTGACGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT195437 WP_003899415.1 NZ_CP071128:c2977230-2976985 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT195437 NZ_CP094722:c1460471-1459872 [Staphylococcus sp. IVB6218]
ATGGCAATGAACTTTAAAATTTTCAAAGATCAAAACACAGCTGCAACATTTGTAGCAGATATTTTAAGAAAACAATTTAG
CAATAATCCAACAACAATTGCAGGGATTCATTTAAAAAATGATGATGCACCGGTTAATGGCGCTTTACAAATTAATGTTG
AAAATAATCCGGTAGATTTTAGTCAAATTCACATTTTAGACTATGATAAAAATGATGCATATTTTAAAGCATTAGGTGTA
CCTGAGAAACAAATTCACGAAATCCCAGAAGATGAAAAAGTAGAAGCATTCATCAAGCATCATGCAAAAACAAAAGAAAA
TAAAGGTAAGCTAACGTTACAAGTCGTGACAATTGATACAGATGGAAGTATTGGTATTCCAATGAATGATGCTGTGTTAA
CGGCACGTGAAATCGTTCTTGTATTAACAGGTGCTGAAAAAGCTGAAGTGGTACGTAAGTTATACGAAGAAAACGGCAGT
ACAACATTTGTCCCATCAAGTTTAAAATCTCATCGTATGGTCAATGTTGTTTTAGATGAAGCAGCAGCACAAGGCTTACC
AGAAGATGTTAGAGCTTATTTCTCAGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References