Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2266802..2267721 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JZL63_RS10545 Protein ID WP_206280169.1
Coordinates 2267116..2267721 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag JZL63_RS10540 Protein ID WP_003410124.1
Coordinates 2266802..2267107 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS10510 2261813..2263069 - 1257 WP_003410095.1 HNH endonuclease -
JZL63_RS10515 2263423..2263998 + 576 WP_003410100.1 hypothetical protein -
JZL63_RS10520 2263995..2265035 + 1041 WP_206280167.1 ImmA/IrrE family metallo-endopeptidase -
JZL63_RS10525 2265277..2265996 + 720 WP_003410108.1 DUF433 domain-containing protein -
JZL63_RS10530 2265986..2266402 + 417 WP_003410114.1 hypothetical protein -
JZL63_RS10535 2266418..2266717 - 300 WP_206280168.1 hypothetical protein -
JZL63_RS10540 2266802..2267107 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
JZL63_RS10545 2267116..2267721 - 606 WP_206280169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZL63_RS10550 2267746..2268105 - 360 WP_003410131.1 hypothetical protein -
JZL63_RS10555 2268265..2268720 - 456 Protein_2086 hypothetical protein -
JZL63_RS10560 2268720..2270237 - 1518 Protein_2087 DEAD/DEAH box helicase -
JZL63_RS10565 2270747..2271745 - 999 WP_003410146.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22730.89 Da        Isoelectric Point: 7.0034

>T195427 WP_206280169.1 NZ_CP071128:c2267721-2267116 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKNG

Download         Length: 606 bp

>T195427 NZ_CP094719:c818401-817940 [Staphylococcus sp. IVB6238]
ATGGGATTATACGAAGAAACTTTAATACAACATGACTATATAGACGTAAGAGAGGCGAATGTACTTCCTGATGATTTAGA
TGGAGTCTGGCTAGGTGATCTAATATTAATTAAACGTAACCTACCAGAAAAGAAGAAAGTCGAAGTCCTTTTTGAAGAAT
TAGCACATCACAAACTTACATACGGTGACATCACCAATCAAAAACAGTTCAACAACCGAAAATTCGAAAATTACGCTAGA
CGCTATTCATACGAAAAGTCTATGCCCCTATCGGGTATAGTCCAGGCGTTTGAGCAAGGGGTACATAATCTGTACGAGCT
TGCTAATTTTTTTGAGATTTCAGAAGGTCACGTACTAGATTGTATTGAGCATTATAAAAAGAAGTATGGTTTACAAGTTA
AATACGGCAAGTATCTAATTAGATTCGAACCGTTAACTATATATAAAGATTTAGCTGATTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT195427 WP_003410124.1 NZ_CP071128:c2267107-2266802 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT195427 NZ_CP094719:c818743-818414 [Staphylococcus sp. IVB6238]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAGCATCTATGAAAAAACAAAATTTGTCGCTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACAAGAGAATTTCCATTAAATCGAGCAGAAGATT
TTGCAAAAGCGCTTAGTATCAGTACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAACAACCACAGCAC
CGCGCAGCTCATTTGGAAGGAGAGCTGACTGATGAAGAGTGGCAACGTGTGTTAGATTATGCAGACTATATTAGAAGCAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References