Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2201716..2202584 | Replicon | chromosome |
| Accession | NZ_CP071128 | ||
| Organism | Mycobacterium tuberculosis strain 267/47W148 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JZL63_RS10170 | Protein ID | WP_010886136.1 |
| Coordinates | 2201716..2202093 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JZL63_RS10175 | Protein ID | WP_206281224.1 |
| Coordinates | 2202135..2202584 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JZL63_RS10120 | 2197505..2197957 | - | 453 | WP_003899095.1 | lipoprotein | - |
| JZL63_RS10125 | 2198021..2198422 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JZL63_RS10130 | 2198415..2198597 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JZL63_RS10135 | 2198711..2199061 | - | 351 | WP_206281223.1 | hypothetical protein | - |
| JZL63_RS10140 | 2199072..2199974 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JZL63_RS10145 | 2199995..2200186 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JZL63_RS10150 | 2200187..2200483 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JZL63_RS10155 | 2200723..2200938 | + | 216 | WP_003409878.1 | antitoxin | - |
| JZL63_RS10160 | 2200935..2201246 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JZL63_RS10165 | 2201220..2201741 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JZL63_RS10170 | 2201716..2202093 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JZL63_RS10175 | 2202135..2202584 | + | 450 | WP_206281224.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JZL63_RS10180 | 2202581..2203126 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JZL63_RS10185 | 2203015..2203629 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JZL63_RS10190 | 2203678..2203974 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JZL63_RS10195 | 2203971..2204222 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JZL63_RS10200 | 2204209..2204703 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JZL63_RS10205 | 2204863..2205270 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JZL63_RS10210 | 2205274..2205546 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JZL63_RS10215 | 2205579..2206799 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T195421 WP_010886136.1 NZ_CP071128:2201716-2202093 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T195421 NZ_CP094717:c1639962-1639609 [Staphylococcus sp. IVB6246]
ATGAAGCGCGGGGATGTATACTTAGCTGATTTATCACCAGTACGGGGTTCTGAACAAGGGGGAGTGAGACCCGTCGTTAT
CATTCAAAATGATACTGGTAACAAATATAGTCCGACTGTTATCGTGGCAGCGATAACAGGTCGTATTAACAAAGCAAAGA
TTCCAACACATGTTGAAATTGAAAAAAAGAAGTATAAGCTCGACAAAGATTCAGTTATTTTATTAGAACAAATTCGAACA
GTAGATAAAAATCGTTTGAAAGAAAAGTTGACTTTTTTATCAGAAGAAAAGATGAAAGAAGTGAATAATGCTTTGGGGAT
TAGTCTTGGCTTACAAGTTGTTCAATCACGATGA
ATGAAGCGCGGGGATGTATACTTAGCTGATTTATCACCAGTACGGGGTTCTGAACAAGGGGGAGTGAGACCCGTCGTTAT
CATTCAAAATGATACTGGTAACAAATATAGTCCGACTGTTATCGTGGCAGCGATAACAGGTCGTATTAACAAAGCAAAGA
TTCCAACACATGTTGAAATTGAAAAAAAGAAGTATAAGCTCGACAAAGATTCAGTTATTTTATTAGAACAAATTCGAACA
GTAGATAAAAATCGTTTGAAAGAAAAGTTGACTTTTTTATCAGAAGAAAAGATGAAAGAAGTGAATAATGCTTTGGGGAT
TAGTCTTGGCTTACAAGTTGTTCAATCACGATGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16751.15 Da Isoelectric Point: 8.0539
>AT195421 WP_206281224.1 NZ_CP071128:2202135-2202584 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDQQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDQQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT195421 NZ_CP094717:c1640133-1639963 [Staphylococcus sp. IVB6246]
ATGTCAGTATTCAATCAAGTGAAGTTTAAAAATTTAGAGCAGTCATTAAAAGAAGGGTACGCCCAAATGGCTGACCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAAGCATGCGATTGCAATGAGTCACACTTATTATCCAAGCATC
AGGATGATTAA
ATGTCAGTATTCAATCAAGTGAAGTTTAAAAATTTAGAGCAGTCATTAAAAGAAGGGTACGCCCAAATGGCTGACCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAAGCATGCGATTGCAATGAGTCACACTTATTATCCAAGCATC
AGGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|