Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2201715..2202583 | Replicon | chromosome |
| Accession | NZ_CP071127 | ||
| Organism | Mycobacterium tuberculosis strain 120/26CAO | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JY387_RS10175 | Protein ID | WP_010886136.1 |
| Coordinates | 2201715..2202092 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JY387_RS10180 | Protein ID | WP_206281224.1 |
| Coordinates | 2202134..2202583 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JY387_RS10125 | 2197504..2197956 | - | 453 | WP_206338253.1 | hypothetical protein | - |
| JY387_RS10130 | 2198020..2198421 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JY387_RS10135 | 2198414..2198596 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JY387_RS10140 | 2198710..2199060 | - | 351 | WP_206281223.1 | hypothetical protein | - |
| JY387_RS10145 | 2199071..2199973 | - | 903 | WP_206338254.1 | hypothetical protein | - |
| JY387_RS10150 | 2199994..2200185 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JY387_RS10155 | 2200186..2200482 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JY387_RS10160 | 2200722..2200937 | + | 216 | WP_003409878.1 | antitoxin | - |
| JY387_RS10165 | 2200934..2201245 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JY387_RS10170 | 2201219..2201740 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JY387_RS10175 | 2201715..2202092 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JY387_RS10180 | 2202134..2202583 | + | 450 | WP_206281224.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JY387_RS10185 | 2202580..2203125 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JY387_RS10190 | 2203014..2203628 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JY387_RS10195 | 2203677..2203973 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JY387_RS10200 | 2203970..2204221 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JY387_RS10205 | 2204208..2204702 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JY387_RS10210 | 2204862..2205269 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JY387_RS10215 | 2205273..2205545 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JY387_RS10220 | 2205578..2206798 | - | 1221 | WP_206338255.1 | TetR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T195360 WP_010886136.1 NZ_CP071127:2201715-2202092 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T195360 NZ_CP094663:c313354-313166 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16751.15 Da Isoelectric Point: 8.0539
>AT195360 WP_206281224.1 NZ_CP071127:2202134-2202583 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDQQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDQQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT195360 NZ_CP094663:c313643-313383 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|