Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2342141..2342658 Replicon chromosome
Accession NZ_CP071104
Organism Staphylococcus aureus strain PS/BAC/317/16/W

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag JYA73_RS11380 Protein ID WP_000251928.1
Coordinates 2342141..2342407 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag JYA73_RS11385 Protein ID WP_000584497.1
Coordinates 2342407..2342658 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA73_RS11355 (JYA73_002274) 2337349..2337885 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
JYA73_RS11360 (JYA73_002275) 2338353..2339177 - 825 WP_000594640.1 formate/nitrite transporter family protein -
JYA73_RS11365 (JYA73_002276) 2339380..2339562 - 183 WP_000079140.1 hypothetical protein -
JYA73_RS11370 (JYA73_002277) 2339648..2340115 - 468 WP_000153340.1 SRPBCC domain-containing protein -
JYA73_RS11375 (JYA73_002278) 2340301..2341848 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JYA73_RS11380 (JYA73_002279) 2342141..2342407 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
JYA73_RS11385 (JYA73_002280) 2342407..2342658 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JYA73_RS11390 (JYA73_002281) 2342822..2342922 - 101 Protein_2211 hypothetical protein -
JYA73_RS11395 (JYA73_002282) 2342929..2343528 - 600 WP_000162804.1 DsbA family protein -
JYA73_RS11400 (JYA73_002283) 2343547..2343909 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JYA73_RS11405 (JYA73_002284) 2344164..2345414 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
JYA73_RS11410 (JYA73_002285) 2345511..2346242 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
JYA73_RS11415 (JYA73_002286) 2346239..2346958 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T195325 WP_000251928.1 NZ_CP071104:c2342407-2342141 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T195325 NZ_CP094526:7854476-7854829 [Bradyrhizobium sp. ISRA464]
TTGGCAACGAAGTCTGGTAACTACTGTCCCGAGGCCGGCGACTTCGTCTGGATCGATCTTGATCCCACGATCGGCCACGA
ACAAAGCGGCCGACGACCGGCCATCGTATTATCGCCGCACAACTACAATGCCGCAGCCGGCCTTTGCGTGATCTGCCCAA
TCACAAGCAGCGTACGCGACTATCCCTTCGAGGCCAAGCTGCCCGACGGCGCCAGCTTTCACGGCGTCGTGCTCGCCGAC
CAACCCCGCAGCATCTCGTGGGAGAAGCGACCGATCCAGCATGCCGGACGAGCGCCTGACGTCCTGCTCACCGAAGTCCG
TGAGCGTTTGGCCGCGTTGCTCGGAATCGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT195325 WP_000584497.1 NZ_CP071104:c2342658-2342407 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT195325 NZ_CP094526:7854241-7854495 [Bradyrhizobium sp. ISRA464]
ATGAAGGTAGCATTTCAGAAGTGGGGCAACAGCCTGGCACTGAGAGTTCCAAAAGCATTCGCCGATGAAATCGGTGCCAG
CGACGGCAAGGCCGCCGAAATGACCGTGAGCGACGGCAAACTGGTGATCGAGATCGCGCGCTCGCCGCGGCGCAAGCGTC
GCTACGCACTCGACAAGCTGGTTGCAGGTATAACGCCGGACAACCGTCATGAAGAGGTTGATTGGGGGCGACCCATTGGC
AACGAAGTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References