Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2316301..2316818 Replicon chromosome
Accession NZ_CP071102
Organism Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JYA70_RS11325 Protein ID WP_000113262.1
Coordinates 2316552..2316818 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JYA70_RS11320 Protein ID WP_000584499.1
Coordinates 2316301..2316552 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA70_RS11290 (2311999) 2311999..2312718 + 720 WP_000479576.1 amino acid ABC transporter permease -
JYA70_RS11295 (2312715) 2312715..2313446 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JYA70_RS11300 (2313543) 2313543..2314793 - 1251 WP_211044206.1 FemA/FemB family glycyltransferase FmhA -
JYA70_RS11305 (2315048) 2315048..2315410 + 363 WP_000819843.1 DUF4467 domain-containing protein -
JYA70_RS11310 (2315429) 2315429..2316028 + 600 WP_000162810.1 DsbA family protein -
JYA70_RS11315 (2316056) 2316056..2316136 + 81 WP_223197974.1 hypothetical protein -
JYA70_RS11320 (2316301) 2316301..2316552 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JYA70_RS11325 (2316552) 2316552..2316818 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JYA70_RS13590 (2316853) 2316853..2316924 + 72 WP_223200558.1 hypothetical protein -
JYA70_RS11330 (2317112) 2317112..2318662 + 1551 WP_000727764.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JYA70_RS11335 (2318848) 2318848..2319315 + 468 WP_000153344.1 SRPBCC domain-containing protein -
JYA70_RS11340 (2319402) 2319402..2319605 + 204 WP_211044207.1 hypothetical protein -
JYA70_RS11345 (2319800) 2319800..2320624 + 825 WP_000572040.1 formate/nitrite transporter family protein -
JYA70_RS11350 (2320858) 2320858..2321394 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T195314 WP_000113262.1 NZ_CP071102:2316552-2316818 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T195314 NZ_CP094523:4296630-4297031 [Bradyrhizobium sp. ISRA443]
ATGCCCGGTGACTTCTTCGACACCAACGTGCTTGTCCACCTCGCGTCGGGCGATCCCTTGAAGGCCGATCGGGCAGAAGC
CGTCATTTCCCGGGGCGGGGTGATTAGCGTTCAGGTGCTGAATGAAATCGCCAATGTCGCGCGCCGCAAGATGCGGATGT
CATGGACGGAGACGCGCGCATTTCTGACGATCTTGCGCAATCTGCTGACGATCTATCCCCTCACGCAGGAGATCCATGAC
GCTGGACTTGATCTGGCCGAGCGCTACGGATTGTCGATGTTCGACGCCATGATCGCCGCCTCCGCGCTTCAGGCCGGTTG
CGACAGATTGTGGTCTGAGGACATGCAGCACAACCAAGTCCTGGATAACAGCCTTCGGATCGTCAATCCGTTTCGGGTCT
AG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT195314 WP_000584499.1 NZ_CP071102:2316301-2316552 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT195314 NZ_CP094523:4296410-4296640 [Bradyrhizobium sp. ISRA443]
ATGCAAGTCGCCAAATGGGGTAACAGCCTCGCGATTCGGCTTCCCGCGGCCGTGGTCGAAGCGCTCGAACTCAAGGAAGG
CGACGAGATCGAAATCCATGTTGCCGACGAGCGGAACTTCGGCGTCGCGCGCAAACCGGGGCGTGAGGAGTTACTGGCGC
GACTGCGCGCCTTCCGCGGACGCCTGCCGGCGGATTTCAAATTCGACCGGGACGAGGCAAATGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References