Detailed information of TA system TA195312

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2290945..2291129
• Replicon: chromosome
• Accession: NZ_CP071102
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JYA70_RS11190
• Protein ID: WP_000482647.1
• Coordinates: 2290945..2291052 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2291069..2291129 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA70_RS11165	2286317..2286790	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
JYA70_RS11170	2286913..2288124	-	1212	WP_001191923.1	multidrug effflux MFS transporter	-
JYA70_RS11175	2288306..2288965	-	660	WP_000831298.1	membrane protein	-
JYA70_RS11180	2289025..2290167	-	1143	WP_001176863.1	glycerate kinase	-
JYA70_RS11185	2290425..2290811	+	387	WP_211044204.1	flippase GtxA	-
JYA70_RS11190	2290945..2291052	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2291069..2291129	-	61	-	-	Antitoxin
JYA70_RS11195	2291756..2293519	+	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
JYA70_RS11200	2293544..2295277	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
JYA70_RS11205	2295544..2295675	+	132	WP_223223631.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T195312 WP_000482647.1 NZ_CP071102:2290945-2291052 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T195312 NZ_CP094522:c27354-26947 [Bradyrhizobium sp. ISRA437]
ATGTATCTCGTCGATACCAATGTGGTCTCCGAGGCTAGGCGCGGCTCGGCGCAGGCCACCGGATGGCTGCGGTCGGTCGA
CCCGGCCAGCGTCCACCTCAGCACCCTCACCCTGGGCGAAATCATGCGCGGCATCGCCCTCAAGCAGAAATCGGACCCGA
AGGCGGCCGCCCATCTGGCCGAATGGTTGCGCAAGCTGCGCCACGACCACGCCGACCGCATCCTGGCGGTGACTGACCAG
ATCTCCGTCGAGTGGGGTCGTATCGCCGCGATCCGGCCGCGCGGCGACATCGACGGGCAGATCGCCGCCACCGCGATCGT
CCACGACCTCATTCTGGTCACCCGCAATGTCGGGGATTTCGAGGATACGGGCGCCACGGTGATCAATCCCTGGGAGGAAT
CGGCATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT195312 NZ_CP071102:c2291129-2291069 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin