Detailed information of TA system TA195311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2259413..2259936
• Replicon: chromosome
• Accession: NZ_CP071102
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: JYA70_RS11050
• Protein ID: WP_000074043.1
• Coordinates: 2259670..2259936 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: JYA70_RS11045
• Protein ID: WP_000587618.1
• Coordinates: 2259413..2259670 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA70_RS11025 (2254494)	2254494..2255687	+	1194	WP_000675406.1	MFS transporter	-
JYA70_RS11030 (2255911)	2255911..2256660	-	750	WP_000072463.1	CPBP family lipoprotein N-acylation protein LnsB	-
JYA70_RS11035 (2256855)	2256855..2258432	+	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
JYA70_RS11040 (2258600)	2258600..2259055	-	456	WP_000732091.1	DUF1307 domain-containing protein	-
JYA70_RS11045 (2259413)	2259413..2259670	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JYA70_RS11050 (2259670)	2259670..2259936	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
JYA70_RS11055 (2260293)	2260293..2261369	+	1077	WP_001076673.1	M42 family metallopeptidase	-
JYA70_RS11060 (2261617)	2261617..2262279	+	663	WP_000923527.1	ATP-binding cassette domain-containing protein	-
JYA70_RS11065 (2262272)	2262272..2263048	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
JYA70_RS11070 (2263444)	2263444..2264631	+	1188	WP_000026189.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T195311 WP_000074043.1 NZ_CP071102:2259670-2259936 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T195311 NZ_CP094521:4296630-4297031 [Bradyrhizobium sp. ISRA437]
ATGCCCGGTGACTTCTTCGACACCAACGTGCTTGTCCACCTCGCGTCGGGCGATCCCTTGAAGGCCGATCGGGCAGAAGC
CGTCATTTCCCGGGGCGGGGTGATTAGCGTTCAGGTGCTGAATGAAATCGCCAATGTCGCGCGCCGCAAGATGCGGATGT
CATGGACGGAGACGCGCGCATTTCTGACGATCTTGCGCAATCTGCTGACGATCTATCCCCTCACGCAGGAGATCCATGAC
GCTGGACTTGATCTGGCCGAGCGCTACGGATTGTCGATGTTCGACGCCATGATCGCCGCCTCCGCGCTTCAGGCCGGTTG
CGACAGATTGTGGTCTGAGGACATGCAGCACAACCAAGTCCTGGATAACAGCCTTCGGATCGTCAATCCGTTTCGGGTCT
AG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT195311 WP_000587618.1 NZ_CP071102:2259413-2259670 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT195311 NZ_CP094521:4296410-4296640 [Bradyrhizobium sp. ISRA437]
ATGCAAGTCGCCAAATGGGGTAACAGCCTCGCGATTCGGCTTCCCGCGGCCGTGGTCGAAGCGCTCGAACTCAAGGAAGG
CGACGAGATCGAAATCCATGTTGCCGACGAGCGGAACTTCGGCGTCGCGCGCAAACCGGGGCGTGAGGAGTTACTGGCGC
GACTGCGCGCCTTCCGCGGACGCCTGCCGGCGGATTTCAAATTCGACCGGGACGAGGCAAATGCCCGGTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2