Detailed information of TA system TA195304

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20167..20505
• Replicon: chromosome
• Accession: NZ_CP071102
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JYA70_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20167..20343 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20331..20505 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA70_RS00090	17855..18007	+	153	WP_000654329.1	hypothetical protein	-
JYA70_RS00095	18054..18341	+	288	WP_001040255.1	hypothetical protein	-
JYA70_RS00100	18397..18771	+	375	WP_000340977.1	hypothetical protein	-
JYA70_RS00105	19183..19965	+	783	WP_000034847.1	staphylococcal enterotoxin type P	-
JYA70_RS00110	20167..20343	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20331..20505	-	175	-	-	Antitoxin
JYA70_RS00120	20555..20809	+	255	WP_000611512.1	phage holin	-
JYA70_RS00125	20821..21576	+	756	WP_000861038.1	CHAP domain-containing protein	-
JYA70_RS00130	21767..22258	+	492	WP_000920038.1	staphylokinase	-
JYA70_RS00135	22908..23243	+	336	Protein_26	SH3 domain-containing protein	-
JYA70_RS00140	23754..24104	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
JYA70_RS00145	24156..24416	-	261	WP_001791826.1	hypothetical protein	-
JYA70_RS00150	24726..24905	-	180	WP_000669791.1	hypothetical protein	-
JYA70_RS00155	25275..25472	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / scn	1..24104	24103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T195304 WP_011447039.1 NZ_CP071102:20167-20343 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T195304 NZ_CP094515:2295123-2295545 [Bradyrhizobium sp. ISRA426]
ATGATCCTGCTCGATACTAATGTGGTCTCCGAGGCGATGAAGCCCGATCCGCACCCAACGGTCCGTGACTGGCTCGACGC
CCAGGCGGCCGAAACGCTGTTTCTCTCCAGCGTCACCATCGCCGAACTGTTGTTCGGCATCGGCGCGCTGCCGCGCGGCA
AGCGCAAGGACAGGCTGGCAGCTGCGCTCGACGGCGTGTTGGACCTGTTCGCAACCCGCATCCTGCCCTTCGATACCGAC
GCGGCGCGGCGCTATGCCGAACTCGCCGTCAAGGCGCGCACGGCCGGAAAAGGCTTCCCCACGCCCGACGGCTACATCGC
TGCGATCGCCGCCGCGCACGGGTTCGCCGTGGCATCGCGCGACACAAGTGCGTTCAATGCCGTCGGTCTGACGATGATCG
ATCCCTGGACCGTGACCAGCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT195304 NZ_CP071102:c20505-20331 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin