Detailed information of TA system TA195302

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2457359..2457543
• Replicon: chromosome
• Accession: NZ_CP071100
• Organism: Staphylococcus aureus strain PS/BAC/169/17/W

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JYA66_RS12210
• Protein ID: WP_000482647.1
• Coordinates: 2457436..2457543 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2457359..2457419 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA66_RS12195	2452813..2452980	-	168	WP_001792506.1	hypothetical protein	-
JYA66_RS12200	2453211..2454944	-	1734	WP_000486496.1	ABC transporter ATP-binding protein	-
JYA66_RS12205	2454969..2456732	-	1764	WP_001064836.1	ABC transporter ATP-binding protein	-
-	2457359..2457419	+	61	-	-	Antitoxin
JYA66_RS12210	2457436..2457543	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
JYA66_RS12215	2457677..2458063	-	387	WP_000779360.1	flippase GtxA	-
JYA66_RS12220	2458321..2459463	+	1143	WP_001176863.1	glycerate kinase	-
JYA66_RS12225	2459523..2460182	+	660	WP_000831295.1	hypothetical protein	-
JYA66_RS12230	2460364..2461575	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JYA66_RS12235	2461698..2462171	-	474	WP_000456492.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T195302 WP_000482647.1 NZ_CP071100:c2457543-2457436 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T195302 NZ_CP094512:c5108082-5107699 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT195302 NZ_CP071100:2457359-2457419 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin