Detailed information of TA system TA195290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1523492..1523799
• Replicon: chromosome
• Accession: NZ_CP071100
• Organism: Staphylococcus aureus strain PS/BAC/169/17/W

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: JYA66_RS07210
• Protein ID: WP_072357969.1
• Coordinates: 1523623..1523799 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1523492..1523631 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA66_RS07175 (1518623)	1518623..1519534	-	912	Protein_1417	DUF1672 domain-containing protein	-
JYA66_RS07180 (1519592)	1519592..1520497	-	906	WP_211020127.1	DUF1672 domain-containing protein	-
JYA66_RS07185 (1520588)	1520588..1520803	-	216	WP_000209712.1	hypothetical protein	-
JYA66_RS07190 (1521176)	1521176..1522012	-	837	WP_000675478.1	hypothetical protein	-
JYA66_RS07195 (1522390)	1522390..1523145	-	756	WP_000861038.1	CHAP domain-containing protein	-
JYA66_RS07200 (1523157)	1523157..1523411	-	255	WP_000611512.1	phage holin	-
JYA66_RS07205 (1523463)	1523463..1523570	+	108	WP_031762631.1	hypothetical protein	-
- (1523492)	1523492..1523631	+	140	NuclAT_0	-	Antitoxin
- (1523492)	1523492..1523631	+	140	NuclAT_0	-	Antitoxin
- (1523492)	1523492..1523631	+	140	NuclAT_0	-	Antitoxin
- (1523492)	1523492..1523631	+	140	NuclAT_0	-	Antitoxin
JYA66_RS07210 (1523623)	1523623..1523799	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
JYA66_RS07215 (1523949)	1523949..1524245	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
JYA66_RS07220 (1524303)	1524303..1524590	-	288	WP_211020129.1	hypothetical protein	-
JYA66_RS07225 (1524637)	1524637..1524789	-	153	WP_001153681.1	hypothetical protein	-
JYA66_RS07230 (1524779)	1524779..1528564	-	3786	WP_211020131.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1520588..1578595	58007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T195290 WP_072357969.1 NZ_CP071100:c1523799-1523623 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T195290 NZ_CP094480:c571-89 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGTTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAGGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTTTATCTTCACCATGGATTTAAGGCATCACAAACTCATGAGCGGACTCTGTTCCTTAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT195290 NZ_CP071100:1523492-1523631 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin