Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 360102..360748 Replicon chromosome
Accession NZ_CP071086
Organism Klebsiella pneumoniae strain 3347689I

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag JY394_RS01665 Protein ID WP_004174016.1
Coordinates 360102..360449 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag JY394_RS01670 Protein ID WP_019725405.1
Coordinates 360449..360748 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY394_RS01655 (JY394_01655) 356028..357461 + 1434 WP_002920564.1 glycogen synthase GlgA -
JY394_RS01660 (JY394_01660) 357479..359926 + 2448 WP_002920561.1 glycogen phosphorylase -
JY394_RS01665 (JY394_01665) 360102..360449 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY394_RS01670 (JY394_01670) 360449..360748 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
JY394_RS01675 (JY394_01675) 360811..362319 - 1509 WP_019704656.1 glycerol-3-phosphate dehydrogenase -
JY394_RS01680 (JY394_01680) 362524..362853 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JY394_RS01685 (JY394_01685) 362904..363734 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JY394_RS01690 (JY394_01690) 363784..364542 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T195258 WP_004174016.1 NZ_CP071086:360102-360449 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T195258 NZ_CP094460:c1075060-1074164 [Burkholderia pyrrocinia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCAGCGCTGCTCGGGCAGTTTCCCGAGCAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGTGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCTGCCGGTGGCTACGGCAGCGCCCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGGTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGATACGC
AGTGGGGGCTGGTATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT195258 WP_019725405.1 NZ_CP071086:360449-360748 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT195258 NZ_CP094460:c1074167-1073313 [Burkholderia pyrrocinia]
ATGAGCGAACCGCTGCAACAAGAACCCGAAAACGGGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCGGAGTTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGTGCGGACAAGGATCGCAACTACAAGCTC
GGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGAG
CCTGCGGGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCGAAGGCGCAGA
GCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGCTTGCCCGCCTATGCGACGACTCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCTCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAGCGCGACGCC
GGAGACGGTCGATGCGTTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGGCGCTGATCGCGGACGGGTTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCGGCT
CAATTACCGCTCGGATGACGAGCACACGTTTATGAAGGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References