Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 47547..47811 Replicon plasmid p3347558_3
Accession NZ_CP071076
Organism Escherichia coli strain 3347558

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag JY392_RS26975 Protein ID WP_001331364.1
Coordinates 47659..47811 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 47547..47609 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY392_RS26960 (43650) 43650..44720 - 1071 WP_031942445.1 IncI1-type conjugal transfer protein TrbB -
JY392_RS26965 (44739) 44739..45947 - 1209 WP_001703845.1 IncI1-type conjugal transfer protein TrbA -
JY392_RS26970 (46253) 46253..47032 - 780 WP_275542888.1 protein FinQ -
- (47547) 47547..47609 - 63 NuclAT_0 - Antitoxin
- (47547) 47547..47609 - 63 NuclAT_0 - Antitoxin
- (47547) 47547..47609 - 63 NuclAT_0 - Antitoxin
- (47547) 47547..47609 - 63 NuclAT_0 - Antitoxin
JY392_RS26975 (47659) 47659..47811 + 153 WP_001331364.1 Hok/Gef family protein Toxin
JY392_RS26980 (47883) 47883..48134 - 252 WP_001291964.1 hypothetical protein -
JY392_RS28165 (48635) 48635..48730 + 96 WP_000609148.1 DinQ-like type I toxin DqlB -
JY392_RS26990 (48795) 48795..48971 - 177 WP_001054898.1 hypothetical protein -
JY392_RS26995 (49154) 49154..49363 - 210 WP_001140543.1 hemolysin expression modulator Hha -
JY392_RS27000 (49461) 49461..50075 - 615 WP_000578648.1 plasmid IncI1-type surface exclusion protein ExcA -
JY392_RS27005 (50151) 50151..52319 - 2169 WP_031942447.1 IncI1-type conjugal transfer membrane protein TraY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / aac(3)-IId / blaTEM-1B - 1..93750 93750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T195232 WP_001331364.1 NZ_CP071076:47659-47811 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T195232 NZ_CP094443:2740438-2740542 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 63 bp

>AT195232 NZ_CP071076:c47609-47547 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References