Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4192400..4193093 Replicon chromosome
Accession NZ_CP071073
Organism Escherichia coli strain 3347558

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JY392_RS20330 Protein ID WP_000415584.1
Coordinates 4192797..4193093 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JY392_RS20325 Protein ID WP_000650107.1
Coordinates 4192400..4192795 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY392_RS20315 (4188264) 4188264..4190522 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JY392_RS20320 (4190660) 4190660..4192267 - 1608 WP_001735743.1 ABC transporter substrate-binding protein -
JY392_RS20325 (4192400) 4192400..4192795 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JY392_RS20330 (4192797) 4192797..4193093 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JY392_RS20335 (4193298) 4193298..4193780 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JY392_RS20340 (4193833) 4193833..4194225 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JY392_RS20345 (4194377) 4194377..4195036 + 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB -
JY392_RS20350 (4195033) 4195033..4196382 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JY392_RS20355 (4196428) 4196428..4196760 - 333 WP_000917684.1 DUF2645 family protein -
JY392_RS20360 (4197079) 4197079..4197660 + 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
JY392_RS20365 (4197691) 4197691..4198005 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T195226 WP_000415584.1 NZ_CP071073:c4193093-4192797 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T195226 NZ_CP094443:c507266-506805 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT195226 WP_000650107.1 NZ_CP071073:c4192795-4192400 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT195226 NZ_CP094443:c507593-507279 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTAATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References