Detailed information of TA system TA195200

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 583611..584023
• Replicon: chromosome
• Accession: NZ_CP071073
• Organism: Escherichia coli strain 3347558

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: JY392_RS02850
• Protein ID: WP_000132601.1
• Coordinates: 583611..583952 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	583947..584023 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY392_RS02840 (581024)	581024..582070	-	1047	WP_147697023.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
JY392_RS02845 (582070)	582070..583449	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JY392_RS02850 (583611)	583611..583952	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
- (583947)	583947..584023	+	77	NuclAT_12	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_12	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_12	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_12	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_13	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_13	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_13	-	Antitoxin
- (583947)	583947..584023	+	77	NuclAT_13	-	Antitoxin
JY392_RS02855 (584180)	584180..585574	-	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
JY392_RS02860 (585571)	585571..587160	-	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	571320..585574	14254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T195200 WP_000132601.1 NZ_CP071073:c583952-583611 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T195200 NZ_CP094358:2712868-2713149 [Abyssalbus ytuae]
GTGATAAAATCTTTTGGTGGTAAGGAAACTGAAGAGATTTGGAATGGAACTCAATCAAAAAAGCTACCGGCTGACATCCA
AAATGTTGCCAGAAGAAAGCTGAGAATGATTAACAATGCACAAAATATAAATGATTTGAGAATTCCTCCGGCAAACCGGT
TAGAAAAATTAAGTGGGAATCTTAAGAAATATTACAGCATTCAAATCAATAAAAGATGGAGAATAATTTTCATATGGAAT
AACGATAATGCTTTTGAAGTTCAAATTGTTGATTATCATTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT195200 NZ_CP071073:583947-584023 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin