195176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3612653..3613310 Replicon chromosome
Accession NZ_CP071063
Organism Enterobacter mori strain 08-091

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JY395_RS16875 Protein ID WP_010434288.1
Coordinates 3612653..3612952 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JY395_RS16880 Protein ID WP_042715349.1
Coordinates 3612963..3613310 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY395_RS16865 (JY395_16850) 3609003..3611195 + 2193 WP_100166237.1 type I secretion system permease/ATPase -
JY395_RS16870 (JY395_16855) 3611206..3612375 + 1170 WP_089598177.1 HlyD family efflux transporter periplasmic adaptor subunit -
JY395_RS16875 (JY395_16860) 3612653..3612952 + 300 WP_010434288.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY395_RS16880 (JY395_16865) 3612963..3613310 + 348 WP_042715349.1 HigA family addiction module antitoxin Antitoxin
JY395_RS16885 (JY395_16870) 3613360..3614541 - 1182 WP_100166238.1 PLP-dependent aminotransferase family protein -
JY395_RS16890 (JY395_16875) 3614562..3615449 - 888 WP_042715351.1 LysR family transcriptional regulator -
JY395_RS16895 (JY395_16880) 3615547..3616149 + 603 WP_042715352.1 short chain dehydrogenase -
JY395_RS16900 (JY395_16885) 3616143..3616877 - 735 WP_215230157.1 class I SAM-dependent methyltransferase -
JY395_RS16905 (JY395_16890) 3616952..3617950 - 999 WP_100166240.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 3609003..3668976 59973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11541.11 Da        Isoelectric Point: 9.6774

>T195176 WP_010434288.1 NZ_CP071063:3612653-3612952 [Enterobacter mori]
MINHFRDQWLMDFFLFGKSSNVIPSSLEAALARKLDIINAASSYRDLRSPPGNMYESLNPPLEGYSSIRVNRQYRLVFRW
TEGKADDLYLSPHKYTSHK

Download         Length: 300 bp

>T195176 NZ_CP094343:1811785-1812354 [Pseudomonas sp. M1]
ATGTTCAGACCGTCACCCATCACCCTGCAGCGCGGTGCGCTGCGCCTGGAGCCCATGGTCGAGGCCGACGTGCCGGACCT
GGTGGCGCTGGCCGAGGCCAACCGCGAGGCGCTGAAGTTCATGAGCGCGCCGCAGCGTCCGGACTGGTACCGCAACAGCC
TCGCCGAGCAGCGCGAGGGCCGCGCCCTGCCGCTGGTGGTGCGCCTGGGCAACCAGCTGGTGGGCACCACCCGTTTCATG
GATTTCCTTCCGGCGCTGCCGGCCTGCGAGATCGGTGGCACCTGGCTGGATGCGGCGCAGCACGGCACCGGGCTGAACGC
CAGCATCAAGTACCTGATGCTGCGTCAGGCCTTCGACAACTGGAAGATGGTCCGCGTGCAGCTGAAGACCGCCGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGGCGCCTGGCCGGC
GGGCGCCTGGACGACAGCGTTCTCTACAGCATCACCGACCTGGAGTGGCCGCAGGTGAAGGCCGCCCTGGAAGCCGGCTT
CATCGGCTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13096.09 Da        Isoelectric Point: 7.0139

>AT195176 WP_042715349.1 NZ_CP071063:3612963-3613310 [Enterobacter mori]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVVEIMAKRKSGQPDVA

Download         Length: 348 bp

>AT195176 NZ_CP094343:1812364-1813224 [Pseudomonas sp. M1]
ATGCCCCTCGACAGCGCCCAGGGCGAGCGCACGCGCTTCTGGCGGGCCCAGGAACTGGGCGGCCTGGAGCTGCTGCACGC
GCGCTTCATCGAGCAGCGCTTCGCCCCCCACGTCCACGAAGGCTTCGCCCTGGTGCTGATCGAGCAGGGCGCCCAGCGCT
TCCGCCACCGCGGCGCCGAGCACCTGGCGCCCAGCGGCAGCCTGGTGCTGATCAATCCCGACGAGGTCCACACCGGCTCC
AAGGCCCATGAGGCGGGCTGGTTGTACCGGGGGTTCTATCCGGAGATCGGCCAGGTCGGCAGCGTGCTCGACGAGCTGGA
GCTGGGCGGCCGCGGCCTGCCCACCTTCGACGCCAGCGTGTTGCACGATACCGAGTTGAGCCGGGCCTTCCTGCACGTGC
ACCGCCTGCTGGAATCCAATGCCAGCAGCCTGGAGCGCCAGACCTGCTGGCGCGAGGCATTGCTGTTGCTGTTCCAGCGC
CACGCGCGGGTGCCCGAGGCGCGGCCGGCCGGCCAGGAACCCCAGGCGGTGGCCCGCGCCCGCGAGCTGCTGGCGGCCCG
GCTGGTCGAGCCGCCGTCGCTGGAAGAACTGGCGGCGGCGGTGAACCTGTCGCCCTTCCACTTCGCCCGGGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGATCAAGCAACGCCGCCTGGAACAGGCCCGCGCCCTGCTCAAGGGCGGCTGC
GCGCCGGCCTCGGTGGCGGCGCAGTTGGGCTACGCCGACCAGAGTCACCTGAGCCGCCAGTTCAAGCAGGCCTACGGCGT
GGCGCCGGGCGAATACCGCCAGGCCTGCGGACGCTCCGGCCTGCCACCTGGCAACCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References