Detailed information of TA system TA195142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3099198..3099706
• Replicon: chromosome
• Accession: NZ_CP071044
• Organism: Streptomyces sp. CA-256286

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JHY03_RS13535
• Protein ID: WP_094213257.1
• Coordinates: 3099446..3099706 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: N0CVS4
• Locus tag: JHY03_RS13530
• Protein ID: WP_015609076.1
• Coordinates: 3099198..3099449 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHY03_RS13520	3095546..3097192	-	1647	WP_031124189.1	PQQ-binding-like beta-propeller repeat protein	-
JHY03_RS13525	3097238..3099058	-	1821	WP_031124188.1	ABC-F family ATP-binding cassette domain-containing protein	-
JHY03_RS13530	3099198..3099449	+	252	WP_015609076.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JHY03_RS13535	3099446..3099706	+	261	WP_094213257.1	Txe/YoeB family addiction module toxin	Toxin
JHY03_RS13540	3099694..3101085	-	1392	WP_094213256.1	acyltransferase	-
JHY03_RS13545	3101339..3101893	+	555	WP_202705313.1	PASTA domain-containing protein	-
JHY03_RS13550	3102006..3102644	+	639	WP_031124185.1	class I SAM-dependent methyltransferase	-
JHY03_RS13555	3102691..3103182	+	492	WP_207564271.1	DUF664 domain-containing protein	-
JHY03_RS13560	3103232..3104137	-	906	WP_094212627.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10438.76 Da
• Isoelectric Point: 9.4245

>T195142 WP_094213257.1 NZ_CP071044:3099446-3099706 [Streptomyces sp. CA-256286]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDVARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T195142 NZ_CP094332:4764509-4764820 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.37 Da
• Isoelectric Point: 4.4118

>AT195142 WP_015609076.1 NZ_CP071044:3099198-3099449 [Streptomyces sp. CA-256286]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVQE
LAE

Nucleotide

• Length: 252 bp

>AT195142 NZ_CP094332:4764817-4765263 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: N0CVS4