Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 330875..331461 Replicon chromosome
Accession NZ_CP071027
Organism Klebsiella pneumoniae strain KP-1Pi

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HZC88_RS01520 Protein ID WP_002920800.1
Coordinates 331093..331461 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HZC88_RS01515 Protein ID WP_004174006.1
Coordinates 330875..331096 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC88_RS01495 (327032) 327032..327958 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HZC88_RS01500 (327955) 327955..329232 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HZC88_RS01505 (329229) 329229..329996 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HZC88_RS01510 (329998) 329998..330711 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HZC88_RS01515 (330875) 330875..331096 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZC88_RS01520 (331093) 331093..331461 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HZC88_RS01525 (331734) 331734..333050 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HZC88_RS01530 (333157) 333157..334044 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HZC88_RS01535 (334041) 334041..334886 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HZC88_RS01540 (334888) 334888..335958 + 1071 WP_032433652.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 327955..336695 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T195114 WP_002920800.1 NZ_CP071027:331093-331461 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T195114 NZ_CP094322:c1816167-1815886 [Edwardsiella anguillarum]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCACCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT195114 WP_004174006.1 NZ_CP071027:330875-331096 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT195114 NZ_CP094322:c1816408-1816157 [Edwardsiella anguillarum]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References