Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13995..14653 Replicon plasmid pRIVM_C010068_1
Accession NZ_CP071026
Organism Enterobacter hormaechei strain RIVM_C010068

Toxin (Protein)


Gene name higB Uniprot ID D3VM97
Locus tag JQL77_RS22405 Protein ID WP_013141682.1
Coordinates 14303..14653 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0K2S392
Locus tag JQL77_RS22400 Protein ID WP_071681528.1
Coordinates 13995..14297 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL77_RS22345 9171..9599 + 429 WP_071681550.1 hypothetical protein -
JQL77_RS22350 9656..10021 + 366 WP_071681548.1 hypothetical protein -
JQL77_RS22355 10015..10461 + 447 WP_071681546.1 Fe3+-siderophore ABC transporter permease -
JQL77_RS22360 10458..10976 + 519 WP_071681544.1 nitrite reductase -
JQL77_RS22365 10976..11206 + 231 WP_081365501.1 hypothetical protein -
JQL77_RS22370 11193..12050 + 858 WP_071681537.1 hypothetical protein -
JQL77_RS22375 11962..12264 + 303 WP_174208834.1 hypothetical protein -
JQL77_RS22380 12280..12807 + 528 WP_071681532.1 thermonuclease family protein -
JQL77_RS22385 12876..13301 + 426 WP_071681530.1 ATP-binding protein -
JQL77_RS22390 13311..13583 + 273 WP_013141679.1 HU family DNA-binding protein -
JQL77_RS22395 13673..13966 + 294 WP_071681628.1 chromosome segregation protein ParM -
JQL77_RS22400 13995..14297 - 303 WP_071681528.1 XRE family transcriptional regulator Antitoxin
JQL77_RS22405 14303..14653 - 351 WP_013141682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQL77_RS22410 15093..15287 + 195 WP_071681524.1 hypothetical protein -
JQL77_RS22415 15298..15669 + 372 WP_071681522.1 hypothetical protein -
JQL77_RS22420 15662..16132 + 471 WP_071681520.1 hypothetical protein -
JQL77_RS22425 16147..16488 - 342 WP_071681518.1 hypothetical protein -
JQL77_RS22430 16585..17088 + 504 WP_071681517.1 DUF1643 domain-containing protein -
JQL77_RS22435 17672..18604 + 933 WP_071681513.1 hypothetical protein -
JQL77_RS22440 18665..19603 + 939 WP_022635571.1 ParB-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / ARR-3 / blaOXA-10 / ant(3'')-Ia / qacE / sul1 / qnrA1 / mph(A) / blaTEM-1B / aac(3)-IId / blaVIM-1 / dfrB1 / catB2 - 1..186213 186213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-89)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13300.16 Da        Isoelectric Point: 5.2421

>T195113 WP_013141682.1 NZ_CP071026:c14653-14303 [Enterobacter hormaechei]
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp

>T195113 NZ_CP094322:c1804533-1804276 [Edwardsiella anguillarum]
ATGCCAGAGATTGATGCCCTGATGGGGCTAAGCTTTGTGATGTATTTCTTCGACAATCAAACTCACAGTTTGCCGCATGT
CCATGTGAAATACGGCGAATTTGAGCTGGTTATCGGGATCGACTCAGGAGAGGCCTTGGAGGGTTACCTTCCCCCTAAAA
AGAGGAAACTGGCCGAGTCACATATTAAGGCCAATAAAACCAGGCTACTGGCTATGTGGCAGATGGCGGTTAATGGGATG
CATCCTGGGAAACTGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10952.72 Da        Isoelectric Point: 9.5936

>AT195113 WP_071681528.1 NZ_CP071026:c14297-13995 [Enterobacter hormaechei]
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRMKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV

Download         Length: 303 bp

>AT195113 NZ_CP094322:c1804266-1803754 [Edwardsiella anguillarum]
ATGTTGAAAATTATTGATGTGGATGTGGTCGGCGACCATGTTATCGAGGTCGAGTTTAGCGACGGCTTCCGTGGTAGGGC
TGATTTAACCGCGCTGTTCAGCAAACCGCCCTTCTCTGCGATCGCCGACTTTAACCGCTTTTCCCTGACGGCCAGCGGCG
TGCTGAACTGGGGAGATGCCGAGCTTTCTGCCGATACGGTTAGGCGCATGAGCAAAGGCGCAGTGGTATCGGCATCCTCA
CGCTCACTCATGCCAGAAAATGTAGAAGCGATCCTCCGCCAGGCCACCTGGGAATCCATGAGCGAGGGGCGCCCGGATAT
TTTGCAAGCCGCGTTAAGGGGATACGCGGAGCAGCTGGGCCACGCGGACGTCATCAAAAGGGCCGGGATTGCCAGCCGCA
GCAGTGCATACAAAACGCTATCGCCATCAACGAACCCCAGCTTTAAATCACTGGCAAAGATCAGCGGCGCGATTTTGGCT
ATCGTGCGTGAAAATAACGCGCAGCACGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A501XS03

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2S392

References