Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4654887..4655489 Replicon chromosome
Accession NZ_CP071017
Organism Enterobacter hormaechei strain RIVM_C019072

Toxin (Protein)


Gene name higB Uniprot ID A0A155DUZ6
Locus tag JQL75_RS22140 Protein ID WP_022649837.1
Coordinates 4655178..4655489 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JQL75_RS22135 Protein ID WP_022649836.1
Coordinates 4654887..4655177 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL75_RS22120 4652385..4653287 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
JQL75_RS22125 4653284..4653919 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
JQL75_RS22130 4653916..4654845 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
JQL75_RS22135 4654887..4655177 - 291 WP_022649836.1 helix-turn-helix domain-containing protein Antitoxin
JQL75_RS22140 4655178..4655489 - 312 WP_022649837.1 hypothetical protein Toxin
JQL75_RS22145 4655638..4656579 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
JQL75_RS22150 4656624..4657061 - 438 WP_022649839.1 D-tyrosyl-tRNA(Tyr) deacylase -
JQL75_RS22155 4657058..4657939 - 882 WP_022649840.1 virulence factor BrkB family protein -
JQL75_RS22160 4657933..4658532 - 600 WP_022649841.1 glucose-1-phosphatase -
JQL75_RS22165 4658651..4659451 - 801 WP_022649842.1 DeoR/GlpR family DNA-binding transcription regulator -
JQL75_RS22170 4659486..4660382 - 897 WP_022649843.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12148.13 Da        Isoelectric Point: 9.4455

>T195048 WP_022649837.1 NZ_CP071017:c4655489-4655178 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T195048 NZ_CP094302:c1905881-1905780 [Edwardsiella anguillarum]
GCAAGGCATTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCATAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGCCAGGTCTTTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10699.21 Da        Isoelectric Point: 10.5888

>AT195048 WP_022649836.1 NZ_CP071017:c4655177-4654887 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Download         Length: 291 bp

>AT195048 NZ_CP094302:1905778-1905888 [Edwardsiella anguillarum]
ATAAAAAAAGACCTGGCACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTATGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAATGCCTTGCTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155DUZ6

Antitoxin

Source ID Structure

References