Detailed information of TA system TA194984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4433035..4433637
• Replicon: chromosome
• Accession: NZ_CP071009
• Organism: Enterobacter hormaechei strain RIVM_C034192

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A155DUZ6
• Locus tag: JQL73_RS21210
• Protein ID: WP_022649837.1
• Coordinates: 4433035..4433346 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JQL73_RS21215
• Protein ID: WP_022649836.1
• Coordinates: 4433347..4433637 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQL73_RS21180	4428142..4429038	+	897	WP_022649843.1	sugar kinase	-
JQL73_RS21185	4429073..4429873	+	801	WP_022649842.1	DeoR/GlpR family DNA-binding transcription regulator	-
JQL73_RS21190	4429992..4430591	+	600	WP_022649841.1	glucose-1-phosphatase	-
JQL73_RS21195	4430585..4431466	+	882	WP_022649840.1	virulence factor BrkB family protein	-
JQL73_RS21200	4431463..4431900	+	438	WP_022649839.1	D-tyrosyl-tRNA(Tyr) deacylase	-
JQL73_RS21205	4431945..4432886	+	942	WP_022649838.1	fatty acid biosynthesis protein FabY	-
JQL73_RS21210	4433035..4433346	+	312	WP_022649837.1	hypothetical protein	Toxin
JQL73_RS21215	4433347..4433637	+	291	WP_022649836.1	helix-turn-helix domain-containing protein	Antitoxin
JQL73_RS21220	4433679..4434608	-	930	WP_022649835.1	formate dehydrogenase accessory protein FdhE	-
JQL73_RS21225	4434605..4435240	-	636	WP_006808711.1	formate dehydrogenase cytochrome b556 subunit	-
JQL73_RS21230	4435237..4436139	-	903	WP_003861960.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12148.13 Da
• Isoelectric Point: 9.4455

>T194984 WP_022649837.1 NZ_CP071009:4433035-4433346 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Nucleotide

• Length: 312 bp

>T194984 NZ_CP094269:310717-311085 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10699.21 Da
• Isoelectric Point: 10.5888

>AT194984 WP_022649836.1 NZ_CP071009:4433347-4433637 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Nucleotide

• Length: 291 bp

>AT194984 NZ_CP094269:310499-310720 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A155DUZ6