Detailed information of TA system TA194967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1735465..1735979
• Replicon: chromosome
• Accession: NZ_CP071001
• Organism: Limosilactobacillus fermentum strain GR1007

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A6C1EMT8
• Locus tag: JYQ67_RS08905
• Protein ID: WP_035437199.1
• Coordinates: 1735465..1735728 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JYQ67_RS08910
• Protein ID: WP_035437201.1
• Coordinates: 1735725..1735979 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYQ67_RS08890	1730941..1731723	+	783	WP_035437193.1	dimethylargininase	-
JYQ67_RS08895	1732111..1733508	+	1398	WP_035437196.1	sodium:proton antiporter	-
JYQ67_RS08900	1733934..1735055	+	1122	WP_080650628.1	PTS sugar transporter subunit IIC	-
JYQ67_RS08905	1735465..1735728	-	264	WP_035437199.1	Txe/YoeB family addiction module toxin	Toxin
JYQ67_RS08910	1735725..1735979	-	255	WP_035437201.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JYQ67_RS08915	1736228..1736515	+	288	WP_041807836.1	transposase	-
JYQ67_RS08920	1736539..1737417	+	879	WP_086031809.1	IS3 family transposase	-
JYQ67_RS08925	1737733..1738194	+	462	WP_204022139.1	hypothetical protein	-
JYQ67_RS08930	1738215..1738979	+	765	WP_080650602.1	zinc ribbon domain-containing protein	-
JYQ67_RS08935	1739186..1740091	-	906	WP_154244344.1	IS3 family transposase	-
JYQ67_RS08940	1740028..1740642	-	615	WP_035431426.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-55)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10252.94 Da
• Isoelectric Point: 10.3349

>T194967 WP_035437199.1 NZ_CP071001:c1735728-1735465 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Nucleotide

• Length: 264 bp

>T194967 NZ_CP094240:2956826-2957212 [Comamonas sp. 7D-2evo2]
ATGCCCGTGTCCGTCCTAGTCGATACATCAGTGTGGGTGAGACATTTTCGTGAGGCAGACACTCACCTGCAGGAATTGCT
TATGCAAGACAGCGTGCTGATGCATTCCATGGTGCATGCAGAGCTGGCCTGTGGTACGCCGCCAGCACCGCGTGCCGACA
CGCTGGCGGCTCTGGCGATGCTGCGGCCGAGCCAGGAGGCATCAATTCCAGAGACTTTGGAATTTCTGGAGCAGAACAAG
CTTTTCGGCAAGGGCTGCGGCTTAGTAGATCTATCGCTGCTTGCCTCTACGCTTATCACTCCTGGCGCCTTACTTTGGAC
TGCAGATCGACGCCTCGCCGACATGGCCACACAGTTGAACGTGGCCTATCTACCGCCTTTGCATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9773.05 Da
• Isoelectric Point: 4.4237

>AT194967 WP_035437201.1 NZ_CP071001:c1735979-1735725 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTRADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Nucleotide

• Length: 255 bp

>AT194967 NZ_CP094240:2956611-2956826 [Comamonas sp. 7D-2evo2]
ATGAGATCGACTTTCACGATCGATGACGATGTCGTAAACCGCGCACGCGCCGTCGCGGCACCCGGTATTGCTGTGCCGGA
ACTGGTACGACTCGCACTGGAAACCTTCACACGTGTCGAGGCAGGTAAGCGTTTGGCTGCGCTCGGCGGTGCCGCGCCAA
ATATGCCCGATGTGCCGCGCCGTGGCAGTGAGGCGGATGCTGAGGACTCACGCTAA

Structures

Toxin

• AlphaFold DB: A0A6C1EMT8