Detailed information of TA system TA194954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2362691..2363208
• Replicon: chromosome
• Accession: NZ_CP070991
• Organism: Staphylococcus aureus strain CBS2016-05

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: JYA46_RS11670
• Protein ID: WP_000113263.1
• Coordinates: 2362942..2363208 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: JYA46_RS11665
• Protein ID: WP_000584499.1
• Coordinates: 2362691..2362942 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA46_RS11635 (2358389)	2358389..2359108	+	720	WP_000479576.1	amino acid ABC transporter permease	-
JYA46_RS11640 (2359105)	2359105..2359836	+	732	WP_072491244.1	amino acid ABC transporter ATP-binding protein	-
JYA46_RS11645 (2359933)	2359933..2361183	-	1251	WP_210994186.1	FemA/FemB family glycyltransferase FmhA	-
JYA46_RS11650 (2361438)	2361438..2361800	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
JYA46_RS11655 (2361819)	2361819..2362418	+	600	WP_098818021.1	DsbA family protein	-
JYA46_RS11660 (2362425)	2362425..2362526	+	102	Protein_2271	hypothetical protein	-
JYA46_RS11665 (2362691)	2362691..2362942	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JYA46_RS11670 (2362942)	2362942..2363208	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
JYA46_RS11675 (2363501)	2363501..2365048	+	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
JYA46_RS11680 (2365234)	2365234..2365701	+	468	WP_000153340.1	SRPBCC domain-containing protein	-
JYA46_RS11685 (2365788)	2365788..2365970	+	183	WP_000079140.1	hypothetical protein	-
JYA46_RS11690 (2366173)	2366173..2366997	+	825	WP_072491245.1	formate/nitrite transporter family protein	-
JYA46_RS11695 (2367411)	2367411..2367947	+	537	WP_098818022.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T194954 WP_000113263.1 NZ_CP070991:2362942-2363208 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T194954 NZ_CP094238:c2762777-2762391 [Comamonas sp. 7D-2]
ATGCCCGTGTCCGTCCTAGTCGATACATCAGTGTGGGTGAGACATTTTCGTGAGGCAGACACTCACCTGCAGGAATTGCT
TATGCAAGACAGCGTGCTGATGCATTCCATGGTGCATGCAGAGCTGGCCTGTGGTACGCCGCCAGCACCGCGTGCCGACA
CGCTGGCGGCTCTGGCGATGCTGCGGCCGAGCCAGGAGGCATCAATTCCAGAGACTTTGGAATTTCTGGAGCAGAACAAG
CTTTTCGGCAAGGGCTGCGGCTTAGTAGATCTATCGCTGCTTGCCTCTACGCTTATCACTCCTGGCGCCTTACTTTGGAC
TGCAGATCGACGCCTCGCCGACATGGCCACACAGTTGAACGTGGCCTATCTACCGCCTTTGCATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT194954 WP_000584499.1 NZ_CP070991:2362691-2362942 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT194954 NZ_CP094238:c2762992-2762777 [Comamonas sp. 7D-2]
ATGAGATCGACTTTCACGATCGATGACGATGTCGTAAACCGCGCACGCGCCGTCGCGGCACCCGGTATTGCTGTGCCGGA
ACTGGTACGACTCGCACTGGAAACCTTCACACGTGTCGAGGCAGGTAAGCGTTTGGCTGCGCTCGGCGGTGCCGCGCCAA
ATATGCCCGATGTGCCGCGCCGTGGCAGTGAGGCGGATGCTGAGGACTCACGCTAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60