Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2306617..2307140 Replicon chromosome
Accession NZ_CP070991
Organism Staphylococcus aureus strain CBS2016-05

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag JYA46_RS11395 Protein ID WP_000074048.1
Coordinates 2306874..2307140 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag JYA46_RS11390 Protein ID WP_000587617.1
Coordinates 2306617..2306874 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA46_RS11370 (2301697) 2301697..2302890 + 1194 WP_072491220.1 MFS transporter -
JYA46_RS11375 (2303114) 2303114..2303863 - 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
JYA46_RS11380 (2304057) 2304057..2305634 + 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
JYA46_RS11385 (2305802) 2305802..2306257 - 456 WP_000732082.1 DUF1307 domain-containing protein -
JYA46_RS11390 (2306617) 2306617..2306874 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JYA46_RS11395 (2306874) 2306874..2307140 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
JYA46_RS11400 (2307496) 2307496..2308572 + 1077 WP_072491221.1 M42 family metallopeptidase -
JYA46_RS11405 (2308917) 2308917..2309579 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
JYA46_RS11410 (2309572) 2309572..2310348 + 777 WP_098818009.1 iron export ABC transporter permease subunit FetB -
JYA46_RS11415 (2310743) 2310743..2311930 + 1188 WP_000026195.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T194951 WP_000074048.1 NZ_CP070991:2306874-2307140 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T194951 NZ_CP094238:c1793850-1793674 [Comamonas sp. 7D-2]
GTGAAAATCAGCGAATTCAAGCGGTGGCTTGAAGCGCAGGGGGTCAAAGTCGAGAACGGTACGAATCACTGGAGGCTGTA
CCACAACGGCAACACAAGCACCCTGCCAAGGCACCCAAGTAAAGAGCTGAAGGAAGGCACAAGACGCGCAATCCTGAAGC
AACTAGGAATCAACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT194951 WP_000587617.1 NZ_CP070991:2306617-2306874 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT194951 NZ_CP094238:c1793608-1793180 [Comamonas sp. 7D-2]
ATGCAAAAGTATCCTGCCCGCTTCGATCCCGCCGACGAAGGGGGCTACACCGTCACGTTTCGGGATATTCCCGAAGCAAT
CACCCAGGGCGATGACCTGGCAGAGGCTGAATCTATGGCGCGTGACGCACTGGTCACGGCCATGGAGTTCTATTTCGAGG
CAGGCCGCGCCGTGCCCGCGCCCAGCAAGGCAGAAAAGGGCGAGCGCCTGGTGGAGCTGCCCGCCAGTGTCGCCGTCAAG
GTGGCGCTGCTGAATGCCCGTCTTGCCACAGGTGCCAGGCCCGCCGACGTGGCCCGCGCCATGGGCGTGAAACCCCAAGA
AATGACCCGCGTTTTTGACCTGGGCCATGCCACCAAGATCGACACCGTTGCGGCCGCGCTGGCTGCCATGGGCTACGAGC
TGGAATTGACCGTGCGCCCGATCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References