194941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2493986..2494509 Replicon chromosome
Accession NZ_CP070986
Organism Staphylococcus aureus strain WBG8287

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag JYH18_RS12255 Protein ID WP_000074048.1
Coordinates 2493986..2494252 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JYH18_RS12260 Protein ID WP_000587616.1
Coordinates 2494252..2494509 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYH18_RS12235 2489292..2490479 - 1188 WP_000026194.1 MFS transporter -
JYH18_RS12240 2490875..2491651 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
JYH18_RS12245 2491644..2492306 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
JYH18_RS12250 2492554..2493630 - 1077 WP_001076671.1 M42 family metallopeptidase -
JYH18_RS12255 2493986..2494252 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
JYH18_RS12260 2494252..2494509 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JYH18_RS12265 2494868..2495323 + 456 WP_000732082.1 DUF1307 domain-containing protein -
JYH18_RS12270 2495491..2497068 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
JYH18_RS12275 2497264..2498013 + 750 WP_000072445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T194941 WP_000074048.1 NZ_CP070986:c2494252-2493986 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T194941 NZ_CP094237:2028975-2029077 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT194941 WP_000587616.1 NZ_CP070986:c2494509-2494252 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT194941 NZ_CP094237:c2029084-2028939 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References