Detailed information of TA system TA194939

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2462796..2462980
• Replicon: chromosome
• Accession: NZ_CP070986
• Organism: Staphylococcus aureus strain WBG8287

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JYH18_RS12115
• Protein ID: WP_000482647.1
• Coordinates: 2462873..2462980 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2462796..2462856 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYH18_RS12100	2458270..2458437	-	168	WP_001790576.1	hypothetical protein	-
JYH18_RS12105	2458668..2460401	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
JYH18_RS12110	2460426..2462189	-	1764	WP_061653160.1	ABC transporter ATP-binding protein/permease	-
-	2462796..2462856	+	61	-	-	Antitoxin
JYH18_RS12115	2462873..2462980	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
JYH18_RS12120	2463114..2463500	-	387	WP_000779360.1	flippase GtxA	-
JYH18_RS12125	2463758..2464900	+	1143	WP_001176871.1	glycerate kinase	-
JYH18_RS12130	2464960..2465619	+	660	WP_000831301.1	membrane protein	-
JYH18_RS12135	2465801..2467012	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JYH18_RS12140	2467135..2467608	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T194939 WP_000482647.1 NZ_CP070986:c2462980-2462873 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T194939 NZ_CP094237:1483733-1484149 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGGATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCTGTCCTGCCCTGGGACCGCGCC
GCAGTGGACGCCACGACGGACATCCGAGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATAGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT194939 NZ_CP070986:2462796-2462856 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin