Detailed information of TA system TA194938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2437439..2437956
• Replicon: chromosome
• Accession: NZ_CP070986
• Organism: Staphylococcus aureus strain WBG8287

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: JYH18_RS11980
• Protein ID: WP_000113262.1
• Coordinates: 2437439..2437705 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: JYH18_RS11985
• Protein ID: WP_000584499.1
• Coordinates: 2437705..2437956 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYH18_RS11955	2432864..2433391	-	528	WP_000973468.1	GNAT family N-acetyltransferase	-
JYH18_RS11960	2433635..2434459	-	825	WP_000572040.1	formate/nitrite transporter family protein	-
JYH18_RS11965	2434676..2434858	-	183	WP_000230294.1	hypothetical protein	-
JYH18_RS11970	2434942..2435409	-	468	WP_000153344.1	SRPBCC domain-containing protein	-
JYH18_RS11975	2435595..2437145	-	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
JYH18_RS11980	2437439..2437705	-	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
JYH18_RS11985	2437705..2437956	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JYH18_RS11990	2438121..2438222	-	102	Protein_2317	hypothetical protein	-
JYH18_RS11995	2438229..2438828	-	600	WP_000162810.1	DsbA family protein	-
JYH18_RS12000	2438847..2439209	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
JYH18_RS12005	2439464..2440714	+	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
JYH18_RS12010	2440811..2441542	-	732	WP_000615458.1	amino acid ABC transporter ATP-binding protein	-
JYH18_RS12015	2441539..2442258	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T194938 WP_000113262.1 NZ_CP070986:c2437705-2437439 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T194938 NZ_CP094237:1470219-1470635 [Klebsiella pneumoniae]
GTGAAAAAGACTTTTATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGCCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAACAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTTAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT194938 WP_000584499.1 NZ_CP070986:c2437956-2437705 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT194938 NZ_CP094237:1469992-1470222 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGTGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60