Detailed information of TA system TA194935

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2184345..2184561
• Replicon: chromosome
• Accession: NZ_CP070986
• Organism: Staphylococcus aureus strain WBG8287

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JYH18_RS10675
• Protein ID: WP_001802298.1
• Coordinates: 2184457..2184561 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2184345..2184400 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYH18_RS10655	2180548..2181213	-	666	WP_001024095.1	SDR family oxidoreductase	-
JYH18_RS10660	2181365..2181685	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JYH18_RS10665	2181687..2182667	+	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
JYH18_RS10670	2182933..2184024	+	1092	WP_000495683.1	hypothetical protein	-
-	2184345..2184400	+	56	-	-	Antitoxin
JYH18_RS10675	2184457..2184561	-	105	WP_001802298.1	hypothetical protein	Toxin
JYH18_RS10680	2185241..2185399	+	159	WP_001792784.1	hypothetical protein	-
JYH18_RS10685	2186058..2186915	-	858	WP_000370917.1	Cof-type HAD-IIB family hydrolase	-
JYH18_RS10690	2186983..2187765	-	783	WP_000908178.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T194935 WP_001802298.1 NZ_CP070986:c2184561-2184457 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T194935 NZ_CP094237:321667-322035 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT194935 NZ_CP070986:2184345-2184400 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin