Detailed information of TA system TA194923

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2449417..2449601
• Replicon: chromosome
• Accession: NZ_CP070983
• Organism: Staphylococcus aureus strain WBG8366

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JX573_RS12225
• Protein ID: WP_000482647.1
• Coordinates: 2449494..2449601 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2449417..2449477 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX573_RS12210	2444947..2445114	-	168	WP_001792506.1	hypothetical protein	-
JX573_RS12215	2445345..2447078	-	1734	WP_000486491.1	ABC transporter ATP-binding protein/permease	-
JX573_RS12220	2447103..2448866	-	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
-	2449417..2449477	+	61	-	-	Antitoxin
JX573_RS12225	2449494..2449601	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
JX573_RS12230	2449735..2450121	-	387	WP_000779347.1	flippase GtxA	-
JX573_RS12235	2450379..2451521	+	1143	WP_001176863.1	glycerate kinase	-
JX573_RS12240	2451581..2452240	+	660	WP_000831298.1	membrane protein	-
JX573_RS12245	2452422..2453633	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JX573_RS12250	2453756..2454229	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T194923 WP_000482647.1 NZ_CP070983:c2449601-2449494 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T194923 NZ_CP094227:c5592590-5592057 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT194923 NZ_CP070983:2449417-2449477 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin