Detailed information of TA system TA194921

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2168491..2168707
• Replicon: chromosome
• Accession: NZ_CP070983
• Organism: Staphylococcus aureus strain WBG8366

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JX573_RS10765
• Protein ID: WP_001802298.1
• Coordinates: 2168603..2168707 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2168491..2168546 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX573_RS10745	2164640..2165305	-	666	WP_001024089.1	SDR family oxidoreductase	-
JX573_RS10750	2165457..2165777	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JX573_RS10755	2165779..2166756	+	978	WP_000019733.1	CDF family zinc efflux transporter CzrB	-
JX573_RS10760	2167022..2168113	+	1092	WP_000495669.1	hypothetical protein	-
-	2168491..2168546	+	56	-	-	Antitoxin
JX573_RS10765	2168603..2168707	-	105	WP_001802298.1	hypothetical protein	Toxin
JX573_RS10770	2169387..2169545	+	159	WP_001792784.1	hypothetical protein	-
JX573_RS10775	2170203..2171060	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
JX573_RS10780	2171128..2171910	-	783	WP_072498841.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T194921 WP_001802298.1 NZ_CP070983:c2168707-2168603 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T194921 NZ_CP094227:5061057-5061467 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT194921 NZ_CP070983:2168491-2168546 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin