Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2020392..2020806 Replicon chromosome
Accession NZ_CP070983
Organism Staphylococcus aureus strain WBG8366

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JX573_RS09965 Protein ID WP_001065046.1
Coordinates 2020555..2020806 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JX573_RS09960 Protein ID WP_000028424.1
Coordinates 2020392..2020565 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX573_RS09900 2015957..2016301 - 345 WP_000817289.1 HNH endonuclease -
JX573_RS09905 2016317..2016769 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
JX573_RS09910 2016884..2017354 - 471 WP_000282758.1 hypothetical protein -
JX573_RS09915 2017377..2017577 - 201 WP_000265041.1 DUF1514 family protein -
JX573_RS09920 2017577..2018226 - 650 Protein_1915 hypothetical protein -
JX573_RS09925 2018385..2018534 - 150 WP_000595305.1 transcriptional activator RinB -
JX573_RS09930 2018531..2018917 - 387 WP_000592201.1 hypothetical protein -
JX573_RS09935 2018914..2019120 - 207 WP_000195803.1 DUF1381 domain-containing protein -
JX573_RS09940 2019117..2019362 - 246 WP_001282074.1 hypothetical protein -
JX573_RS09945 2019399..2019932 - 534 WP_001061838.1 dUTP diphosphatase -
JX573_RS09950 2019947..2020108 - 162 WP_164492492.1 hypothetical protein -
JX573_RS09955 2020109..2020366 - 258 WP_000248921.1 hypothetical protein -
JX573_RS09960 2020392..2020565 - 174 WP_000028424.1 hypothetical protein Antitoxin
JX573_RS09965 2020555..2020806 - 252 WP_001065046.1 DUF1024 family protein Toxin
JX573_RS09970 2020821..2021063 - 243 WP_000131381.1 phi PVL orf 51-like protein -
JX573_RS09975 2021067..2021435 - 369 WP_000101270.1 hypothetical protein -
JX573_RS09980 2021448..2021903 - 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
JX573_RS09985 2021912..2022130 - 219 WP_000338527.1 hypothetical protein -
JX573_RS09990 2022137..2023030 - 894 WP_000148327.1 DnaD domain-containing protein -
JX573_RS09995 2023060..2023530 - 471 WP_000934762.1 single-stranded DNA-binding protein -
JX573_RS10000 2023531..2024148 - 618 WP_072353921.1 MBL fold metallo-hydrolase -
JX573_RS10005 2024229..2025149 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 1992044..2045722 53678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T194918 WP_001065046.1 NZ_CP070983:c2020806-2020555 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T194918 NZ_CP094227:4476984-4478306 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT194918 WP_000028424.1 NZ_CP070983:c2020565-2020392 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT194918 NZ_CP094227:4476718-4476984 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References