Detailed information of TA system TA194915

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1995675..1995982
• Replicon: chromosome
• Accession: NZ_CP070983
• Organism: Staphylococcus aureus strain WBG8366

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: JX573_RS09795
• Protein ID: WP_072353918.1
• Coordinates: 1995806..1995982 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1995675..1995814 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX573_RS09755	1991241..1991420	+	180	WP_000669791.1	hypothetical protein	-
JX573_RS09760	1991731..1991991	+	261	WP_001791826.1	hypothetical protein	-
JX573_RS09765	1992044..1992394	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
JX573_RS09770	1992905..1993240	-	336	Protein_1885	SH3 domain-containing protein	-
JX573_RS09775	1993891..1994382	-	492	WP_000920038.1	staphylokinase	-
JX573_RS09780	1994573..1995328	-	756	WP_000861038.1	CHAP domain-containing protein	-
JX573_RS09785	1995340..1995594	-	255	WP_000611512.1	phage holin	-
JX573_RS09790	1995646..1995753	+	108	WP_001791821.1	hypothetical protein	-
-	1995675..1995814	+	140	NuclAT_0	-	Antitoxin
-	1995675..1995814	+	140	NuclAT_0	-	Antitoxin
-	1995675..1995814	+	140	NuclAT_0	-	Antitoxin
-	1995675..1995814	+	140	NuclAT_0	-	Antitoxin
JX573_RS09795	1995806..1995982	-	177	WP_072353918.1	putative holin-like toxin	Toxin
JX573_RS09800	1996125..1996499	-	375	WP_000340977.1	hypothetical protein	-
JX573_RS09805	1996555..1996842	-	288	WP_001262620.1	hypothetical protein	-
JX573_RS09810	1996888..1997040	-	153	WP_001000058.1	hypothetical protein	-
JX573_RS09815	1997033..2000815	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1992044..2045722	53678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T194915 WP_072353918.1 NZ_CP070983:c1995982-1995806 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T194915 NZ_CP094227:c4138005-4137903 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 140 bp

>AT194915 NZ_CP070983:1995675-1995814 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin