194865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3361526..3362301 Replicon chromosome
Accession NZ_CP070970
Organism Klebsiella pneumoniae strain JS706

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag JXZ99_RS16640 Protein ID WP_004150910.1
Coordinates 3361526..3362011 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JXZ99_RS16645 Protein ID WP_004150912.1
Coordinates 3362008..3362301 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JXZ99_RS16615 3356695..3358062 - 1368 WP_004150905.1 replicative DNA helicase -
JXZ99_RS16620 3358055..3358438 - 384 WP_004150906.1 hypothetical protein -
JXZ99_RS16625 3358438..3359310 - 873 WP_004188557.1 ParA family protein -
JXZ99_RS16630 3359916..3360132 - 217 Protein_3260 transposase -
JXZ99_RS16635 3360229..3360822 - 594 WP_004188553.1 hypothetical protein -
JXZ99_RS16640 3361526..3362011 - 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
JXZ99_RS16645 3362008..3362301 - 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JXZ99_RS16650 3362946..3364322 + 1377 WP_004217775.1 cystathionine beta-synthase -
JXZ99_RS16655 3364333..3365481 + 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JXZ99_RS16660 3365482..3366393 - 912 WP_004188550.1 LysR family transcriptional regulator -
JXZ99_RS16665 3366491..3367093 + 603 WP_002916735.1 short chain dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 3303439..3362552 59113
flank IS/Tn - - 3359980..3360132 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T194865 WP_004150910.1 NZ_CP070970:c3362011-3361526 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T194865 NZ_CP094138:c1569495-1569214 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAACATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTATT
TTATTGCGTCTAGACACTCACAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT194865 WP_004150912.1 NZ_CP070970:c3362301-3362008 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT194865 NZ_CP094138:c1569802-1569488 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATAAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAAGAGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTGAATACAATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References