Detailed information of TA system TA194840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 56023..56542
• Replicon: chromosome
• Accession: NZ_CP070964
• Organism: Staphylococcus sp. SB1-57

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JX000_RS00235
• Protein ID: WP_107532818.1
• Coordinates: 56270..56542 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2T4PYE3
• Locus tag: JX000_RS00230
• Protein ID: WP_002466398.1
• Coordinates: 56023..56277 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX000_RS00215	52243..52563	+	321	WP_206140744.1	hypothetical protein	-
JX000_RS00220	53011..53448	+	438	WP_145506246.1	hypothetical protein	-
JX000_RS00225	53575..55776	-	2202	WP_206140745.1	YSIRK-type signal peptide-containing protein	-
JX000_RS00230	56023..56277	+	255	WP_002466398.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JX000_RS00235	56270..56542	+	273	WP_107532818.1	Txe/YoeB family addiction module toxin	Toxin
JX000_RS00240	56936..58306	+	1371	WP_002450206.1	citrate:proton symporter	-
JX000_RS00245	58399..59037	-	639	WP_049425548.1	NAD(P)H-dependent oxidoreductase	-
JX000_RS00250	59330..60760	+	1431	WP_206140746.1	DHA2 family efflux MFS transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10837.66 Da
• Isoelectric Point: 9.9029

>T194840 WP_107532818.1 NZ_CP070964:56270-56542 [Staphylococcus sp. SB1-57]
MSRLNILFTPDAFEDYKYWQILDKKLLKKINHLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYHYFK

Nucleotide

• Length: 273 bp

>T194840 NZ_CP094117:577200-577466 [Helicobacter pylori]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCATTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTGGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9345.27 Da
• Isoelectric Point: 4.0334

>AT194840 WP_002466398.1 NZ_CP070964:56023-56277 [Staphylococcus sp. SB1-57]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ESYE

Nucleotide

• Length: 255 bp

>AT194840 NZ_CP094117:576842-577219 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCACTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T4PYE3