Detailed information of TA system TA194827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4485083..4485305
• Replicon: chromosome
• Accession: NZ_CP070962
• Organism: Escherichia coli strain K-12 J53

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: JTR57_RS21780
• Protein ID: WP_000141634.1
• Coordinates: 4485198..4485305 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4485083..4485149 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTR57_RS21760	4480524..4481426	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
JTR57_RS21765	4481437..4482420	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
JTR57_RS21770	4482417..4483421	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JTR57_RS21775	4483451..4484722	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	4485083..4485149	-	67	-	-	Antitoxin
JTR57_RS21780	4485198..4485305	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
JTR57_RS21785	4485392..4487071	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
JTR57_RS21790	4487068..4487259	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JTR57_RS21795	4487256..4488827	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
JTR57_RS21800	4489100..4489288	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
JTR57_RS21805	4489324..4490052	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T194827 WP_000141634.1 NZ_CP070962:4485198-4485305 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T194827 NZ_CP094102:145287-145568 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACGAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGGGAATGCCATGTTAAGCCAAACTTACTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT194827 NZ_CP070962:c4485149-4485083 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin